Cargando…

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

Glycans from microbial pathogens are well known pathogen-associated molecular patterns that are recognized by the host immunity; however, little is known about whether and how mammalian self-glycans activate the host immune response, especially in the context of autoimmune disease. Using biochemical...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fermaintt, Charles S., Sano, Kanae, Liu, Zhida, Ishii, Nozomi, Seino, Junichi, Dobbs, Nicole, Suzuki, Tadashi, Fu, Yang-Xin, Lehrman, Mark A., Matsuo, Ichiro, Yan, Nan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542856/ https://www.ncbi.nlm.nih.gov/pubmed/31147550 http://dx.doi.org/10.1038/s41467-019-10319-5

Ejemplares similares

PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling
por: Lin, Yongfang, et al.
Publicado: (2023)

Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
por: Zhang, Min, et al.
Publicado: (2022)

Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1
por: Tsuchiya, Yuko, et al.
Publicado: (2016)

Radiation Induces Bone Microenvironment Disruption by Activating the STING-TBK1 Pathway
por: Wang, Yuyang, et al.
Publicado: (2023)

Synergistic Effects of Azithromycin and STING Agonist Promote IFN-I Production by Enhancing the Activation of STING-TBK1 Signaling
por: Petcharat, Kanoktip, et al.
Publicado: (2023)

A Conserved PLPLRT/SD Motif of STING Mediates the Recruitment and Activation of TBK1
por: Zhao, Baoyu, et al.
Publicado: (2019)

TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance
por: Li, Tong, et al.
Publicado: (2021)

Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signaling
por: Nandakumar, Ramya, et al.
Publicado: (2019)

Evaluation and use of disaccharides as energy source in protein-free mammalian cell cultures
por: Leong, Dawn Sow Zong, et al.
Publicado: (2017)

Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway
por: Ding, Chunyong, et al.
Publicado: (2020)

The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis
por: Occhigrossi, Luca, et al.
Publicado: (2023)

PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation
por: Li, Zexing, et al.
Publicado: (2015)

Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA
por: Fermaintt, Charles S., et al.
Publicado: (2021)

Priming of the cGAS-STING-TBK1 Pathway Enhances LPS-Induced Release of Type I Interferons
por: Tesser, Alessandra, et al.
Publicado: (2021)

Aberrant Activation of the STING-TBK1 Pathway in γδ T Cells Regulates Immune Responses in Oral Lichen Planus
por: Huang, Shan, et al.
Publicado: (2023)

Disaccharide-tag for highly sensitive identification of O-GlcNAc-modified proteins in mammalian cells
por: Abo, Hirohito, et al.
Publicado: (2022)

Pharmacological Inhibition of STING/TBK1 Signaling Attenuates Myeloid Fibroblast Activation and Macrophage to Myofibroblast Transition in Renal Fibrosis
por: Zeng, Haimei, et al.
Publicado: (2022)

Feline Panleucopenia Virus NS2 Suppresses the Host IFN-β Induction by Disrupting the Interaction between TBK1 and STING
por: Kang, Hongtao, et al.
Publicado: (2017)

cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection
por: Li, Qiang, et al.
Publicado: (2019)

The cGAS/STING–TBK1–IRF Regulatory Axis Orchestrates a Primitive Interferon-Like Antiviral Mechanism in Oyster
por: Qiao, Xue, et al.
Publicado: (2021)

Synthesis and Reactivity of 4′-Deoxypentenosyl Disaccharides
por: Padungros, Panuwat, et al.
Publicado: (2014)

Total Synthesis of Natural Disaccharide Sambubiose
por: Lucarini, Simone, et al.
Publicado: (2020)

Effects of the naturally‐occurring disaccharides, palatinose and sucrose, on incretin secretion in healthy non‐obese subjects
por: Maeda, Aya, et al.
Publicado: (2013)

Epistatic effect of TLR3 and cGAS‐STING‐IKKε‐TBK1‐IFN signaling variants on colorectal cancer risk
por: Catalano, Calogerina, et al.
Publicado: (2019)

429 Eribulin Synergizes with STING Agonists by Enhancing Type 1 Interferon Expression and Improves Antitumor Efficacy as Combination Treatment
por: Takahashi-Ruiz, Leila, et al.
Publicado: (2023)

Lactulose, Disaccharides and Colonic Flora: Clinical Consequences
por: Clausen, Mette Rye, et al.
Publicado: (2012)

The Microtubule Destabilizer Eribulin Synergizes with STING Agonists to Promote Antitumor Efficacy in Triple-Negative Breast Cancer Models
por: Takahashi-Ruiz, Leila, et al.
Publicado: (2022)

The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity
por: Xiao, Yichuan, et al.
Publicado: (2017)

TBC1D9 regulates TBK1 activation through Ca(2+) signaling in selective autophagy
por: Nozawa, Takashi, et al.
Publicado: (2020)

Manassantin B shows antiviral activity against coxsackievirus B3 infection by activation of the STING/TBK-1/IRF3 signalling pathway
por: Song, Jae-Hyoung, et al.
Publicado: (2019)

The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels
por: Basit, Abdul, et al.
Publicado: (2020)

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
por: Yum, Seoyun, et al.
Publicado: (2021)

B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
por: Lee, Michelle S.J., et al.
Publicado: (2021)

Marine diterpenoid targets STING palmitoylation in mammalian cells
por: Hsiao, Wan-Chi, et al.
Publicado: (2023)

Evidence for an Essential Deglycosylation-Independent Activity of PNGase in Drosophila melanogaster
por: Funakoshi, Yoko, et al.
Publicado: (2010)

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex
por: Chen, Xiaojuan, et al.
Publicado: (2014)

CRISPR/Cas9-Mediated Chicken TBK1 Gene Knockout and Its Essential Role in STING-Mediated IFN-β Induction in Chicken Cells
por: Cheng, Yuqiang, et al.
Publicado: (2019)

A Nanoparticle-Conjugated Anti-TBK1 siRNA Induces Autophagy-Related Apoptosis and Enhances cGAS-STING Pathway in GBM Cells
por: Xu, Shengchao, et al.
Publicado: (2021)

Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia
por: Yilmaz, Ismail Cem, et al.
Publicado: (2022)

Stimulation of the Labellar Sugar Receptor of the Fleshfly by Mono- and Disaccharides
por: Morita, Hiromichi, et al.
Publicado: (1968)

Cannot write session to /tmp/vufind_sessions/sess_a1u3hsdfbr64te4uc6vsijvu69