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Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma

Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report the therapeutic efficacy of celastrol as a promising candidate compound for treatment of pancreatic carcinoma via n...

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Detalles Bibliográficos
Autores principales: Cao, Xi, Hu, Ying, Luo, Shi, Wang, Yuejing, Gong, Tao, Sun, Xun, Fu, Yao, Zhang, Zhirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543032/
https://www.ncbi.nlm.nih.gov/pubmed/31193785
http://dx.doi.org/10.1016/j.apsb.2018.12.009
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author Cao, Xi
Hu, Ying
Luo, Shi
Wang, Yuejing
Gong, Tao
Sun, Xun
Fu, Yao
Zhang, Zhirong
author_facet Cao, Xi
Hu, Ying
Luo, Shi
Wang, Yuejing
Gong, Tao
Sun, Xun
Fu, Yao
Zhang, Zhirong
author_sort Cao, Xi
collection PubMed
description Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report the therapeutic efficacy of celastrol as a promising candidate compound for treatment of pancreatic carcinoma via naïve neutrophil membrane-coated poly(ethylene glycol) methyl ether-block-poly(lactic-co-glycolic acid) (PEG-PLGA) nanoparticles. Neutrophil membrane-coated nanoparticles (NNPs) are well demonstrated to overcome the blood pancreas barrier to achieve pancreas-specific drug delivery in vivo. Using tumor-bearing mice xenograft model, NNPs showed selective accumulations at the tumor site following systemic administration as compared to nanoparticles without neutrophil membrane coating. In both orthotopic and ectopic tumor models, celastrol-loaded NNPs demonstrated greatly enhanced tumor inhibition which significantly prolonged the survival of tumor bearing mice and minimizing liver metastases. Overall, these results suggest that celastrol-loaded NNPs represent a viable and effective treatment option for pancreatic carcinoma.
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spelling pubmed-65430322019-06-03 Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma Cao, Xi Hu, Ying Luo, Shi Wang, Yuejing Gong, Tao Sun, Xun Fu, Yao Zhang, Zhirong Acta Pharm Sin B Original article Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report the therapeutic efficacy of celastrol as a promising candidate compound for treatment of pancreatic carcinoma via naïve neutrophil membrane-coated poly(ethylene glycol) methyl ether-block-poly(lactic-co-glycolic acid) (PEG-PLGA) nanoparticles. Neutrophil membrane-coated nanoparticles (NNPs) are well demonstrated to overcome the blood pancreas barrier to achieve pancreas-specific drug delivery in vivo. Using tumor-bearing mice xenograft model, NNPs showed selective accumulations at the tumor site following systemic administration as compared to nanoparticles without neutrophil membrane coating. In both orthotopic and ectopic tumor models, celastrol-loaded NNPs demonstrated greatly enhanced tumor inhibition which significantly prolonged the survival of tumor bearing mice and minimizing liver metastases. Overall, these results suggest that celastrol-loaded NNPs represent a viable and effective treatment option for pancreatic carcinoma. Elsevier 2019-05 2018-12-26 /pmc/articles/PMC6543032/ /pubmed/31193785 http://dx.doi.org/10.1016/j.apsb.2018.12.009 Text en © 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original article
Cao, Xi
Hu, Ying
Luo, Shi
Wang, Yuejing
Gong, Tao
Sun, Xun
Fu, Yao
Zhang, Zhirong
Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma
title Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma
title_full Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma
title_fullStr Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma
title_full_unstemmed Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma
title_short Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma
title_sort neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma
topic Original article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543032/
https://www.ncbi.nlm.nih.gov/pubmed/31193785
http://dx.doi.org/10.1016/j.apsb.2018.12.009
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