Cargando…

Impact of tumor sidedness on survival and recurrence patterns in colon cancer patients

PURPOSE: Previous studies have reported conflicting results regarding the prognostic value of tumor sidedness in colon cancer. We investigated the oncologic impact of tumor location and examined whether recurrence patterns were related to tumor sidedness in colon cancer patients. METHODS: We identif...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jong Min, Han, Yoon Dae, Cho, Min Soo, Hur, Hyuk, Min, Byung Soh, Lee, Kang Young, Kim, Nam Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543053/
https://www.ncbi.nlm.nih.gov/pubmed/31183334
http://dx.doi.org/10.4174/astr.2019.96.6.296
_version_ 1783423025837768704
author Lee, Jong Min
Han, Yoon Dae
Cho, Min Soo
Hur, Hyuk
Min, Byung Soh
Lee, Kang Young
Kim, Nam Kyu
author_facet Lee, Jong Min
Han, Yoon Dae
Cho, Min Soo
Hur, Hyuk
Min, Byung Soh
Lee, Kang Young
Kim, Nam Kyu
author_sort Lee, Jong Min
collection PubMed
description PURPOSE: Previous studies have reported conflicting results regarding the prognostic value of tumor sidedness in colon cancer. We investigated the oncologic impact of tumor location and examined whether recurrence patterns were related to tumor sidedness in colon cancer patients. METHODS: We identified stage I–III colon adenocarcinoma patients from a prospective colorectal cancer registry at Severance Hospital, Seoul, Korea, who underwent complete mesocolic excision between 2005 and 2012. Adjusted hazard ratios (HRs) and 95% confidence intervals (CI) for predictors of cancer-specific survival (CSS), recurrence-free survival (RFS), and cumulative recurrence at specific anatomic sites were examined using Cox proportional hazard regression analysis. RESULTS: Overall, 1,912 patients, 1,077 (56.3%) with left-sided colon cancer (LCC), and 835 (43.7%) with right-sided colon cancer (RCC), at a median follow-up of 59 months, were eligible and included in the study. In univariate analysis, similar 5-year CSS and RFS were observed for LCC and RCC in the total patient population, and when stratified by stage for stage I and II patients. For stage III patients, an adjusted Cox regression analysis indicated that RCC patients had a higher risk of cancer-specific mortality (HR, 1.75; 95% CI, 1.07–2.86; P = 0.024) and recurrence (HR, 1.78; 95% CI, 1.22–2.60; P = 0.003). Furthermore, RCC was an independent predictor of peritoneal recurrence (HR, 1.86; 95% CI, 1.05–3.29; P = 0.031) in stage III patients. CONCLUSION: RCC correlated with worse CSS and RFS than LCC. In stage III patients, RCC correlated with increased risk of peritoneal recurrence. The reasons for these differences remain to be investigated.
format Online
Article
Text
id pubmed-6543053
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher The Korean Surgical Society
record_format MEDLINE/PubMed
spelling pubmed-65430532019-06-11 Impact of tumor sidedness on survival and recurrence patterns in colon cancer patients Lee, Jong Min Han, Yoon Dae Cho, Min Soo Hur, Hyuk Min, Byung Soh Lee, Kang Young Kim, Nam Kyu Ann Surg Treat Res Original Article PURPOSE: Previous studies have reported conflicting results regarding the prognostic value of tumor sidedness in colon cancer. We investigated the oncologic impact of tumor location and examined whether recurrence patterns were related to tumor sidedness in colon cancer patients. METHODS: We identified stage I–III colon adenocarcinoma patients from a prospective colorectal cancer registry at Severance Hospital, Seoul, Korea, who underwent complete mesocolic excision between 2005 and 2012. Adjusted hazard ratios (HRs) and 95% confidence intervals (CI) for predictors of cancer-specific survival (CSS), recurrence-free survival (RFS), and cumulative recurrence at specific anatomic sites were examined using Cox proportional hazard regression analysis. RESULTS: Overall, 1,912 patients, 1,077 (56.3%) with left-sided colon cancer (LCC), and 835 (43.7%) with right-sided colon cancer (RCC), at a median follow-up of 59 months, were eligible and included in the study. In univariate analysis, similar 5-year CSS and RFS were observed for LCC and RCC in the total patient population, and when stratified by stage for stage I and II patients. For stage III patients, an adjusted Cox regression analysis indicated that RCC patients had a higher risk of cancer-specific mortality (HR, 1.75; 95% CI, 1.07–2.86; P = 0.024) and recurrence (HR, 1.78; 95% CI, 1.22–2.60; P = 0.003). Furthermore, RCC was an independent predictor of peritoneal recurrence (HR, 1.86; 95% CI, 1.05–3.29; P = 0.031) in stage III patients. CONCLUSION: RCC correlated with worse CSS and RFS than LCC. In stage III patients, RCC correlated with increased risk of peritoneal recurrence. The reasons for these differences remain to be investigated. The Korean Surgical Society 2019-06 2019-05-29 /pmc/articles/PMC6543053/ /pubmed/31183334 http://dx.doi.org/10.4174/astr.2019.96.6.296 Text en Copyright © 2019, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/4.0/ Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Jong Min
Han, Yoon Dae
Cho, Min Soo
Hur, Hyuk
Min, Byung Soh
Lee, Kang Young
Kim, Nam Kyu
Impact of tumor sidedness on survival and recurrence patterns in colon cancer patients
title Impact of tumor sidedness on survival and recurrence patterns in colon cancer patients
title_full Impact of tumor sidedness on survival and recurrence patterns in colon cancer patients
title_fullStr Impact of tumor sidedness on survival and recurrence patterns in colon cancer patients
title_full_unstemmed Impact of tumor sidedness on survival and recurrence patterns in colon cancer patients
title_short Impact of tumor sidedness on survival and recurrence patterns in colon cancer patients
title_sort impact of tumor sidedness on survival and recurrence patterns in colon cancer patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543053/
https://www.ncbi.nlm.nih.gov/pubmed/31183334
http://dx.doi.org/10.4174/astr.2019.96.6.296
work_keys_str_mv AT leejongmin impactoftumorsidednessonsurvivalandrecurrencepatternsincoloncancerpatients
AT hanyoondae impactoftumorsidednessonsurvivalandrecurrencepatternsincoloncancerpatients
AT chominsoo impactoftumorsidednessonsurvivalandrecurrencepatternsincoloncancerpatients
AT hurhyuk impactoftumorsidednessonsurvivalandrecurrencepatternsincoloncancerpatients
AT minbyungsoh impactoftumorsidednessonsurvivalandrecurrencepatternsincoloncancerpatients
AT leekangyoung impactoftumorsidednessonsurvivalandrecurrencepatternsincoloncancerpatients
AT kimnamkyu impactoftumorsidednessonsurvivalandrecurrencepatternsincoloncancerpatients