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Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease

BACKGROUND: Gender-related factors might play an important role in the development of reflux esophagitis (RE) and symptomatic gastro-esophageal reflux disease (GERD). We aimed to evaluate the prevalence and risk factors for RE and symptomatic GERD and determine whether gender specific differences ex...

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Autores principales: Kim, Sang Yoon, Jung, Hye-Kyung, Lim, Jiyoung, Kim, Tae Oh, Choe, A Reum, Tae, Chung Hyun, Shim, Ki-Nam, Moon, Chang Mo, Kim, Seong-Eun, Jung, Sung-Ae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543060/
https://www.ncbi.nlm.nih.gov/pubmed/31144481
http://dx.doi.org/10.3346/jkms.2019.34.e158
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author Kim, Sang Yoon
Jung, Hye-Kyung
Lim, Jiyoung
Kim, Tae Oh
Choe, A Reum
Tae, Chung Hyun
Shim, Ki-Nam
Moon, Chang Mo
Kim, Seong-Eun
Jung, Sung-Ae
author_facet Kim, Sang Yoon
Jung, Hye-Kyung
Lim, Jiyoung
Kim, Tae Oh
Choe, A Reum
Tae, Chung Hyun
Shim, Ki-Nam
Moon, Chang Mo
Kim, Seong-Eun
Jung, Sung-Ae
author_sort Kim, Sang Yoon
collection PubMed
description BACKGROUND: Gender-related factors might play an important role in the development of reflux esophagitis (RE) and symptomatic gastro-esophageal reflux disease (GERD). We aimed to evaluate the prevalence and risk factors for RE and symptomatic GERD and determine whether gender specific differences exist. METHODS: This study was conducted on a health cohort consisting of 10,158 participants who underwent comprehensive health screening. Lifestyles and gastrointestinal symptoms were investigated using a self-reported structured questionnaire. Questionnaires about menstrual status were added for the women. RESULTS: The prevalence of RE in men was significantly higher than that in women (10.6% vs. 2.0%, P < 0.001); however, symptomatic GERD showed predominance in women (6.2% vs. 2.5%, P < 0.001). Although the prevalence of RE gradually increased with the duration of menopause stratified by decade (P = 0.007), that of symptomatic GERD rapidly increased across the menopausal transit in women. Apart from common risk factors of obesity and current smoking for RE, over 70 years of age in women and hiatal hernia and hypertriglyceridemia in men were significant risk factors. In symptomatic GERD, high somatization was a common risk factor. Excessive alcohol drinking was a significant risk factor in men, but not in women. CONCLUSION: This study showed a predominance of RE in men, but a predominance of symptomatic GERD in women. In women, dynamic increase in the prevalence of GERD is closely related to the menopause conditions and its duration. There are specific risk factors for RE and symptomatic GERD according to gender differences.
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spelling pubmed-65430602019-06-05 Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease Kim, Sang Yoon Jung, Hye-Kyung Lim, Jiyoung Kim, Tae Oh Choe, A Reum Tae, Chung Hyun Shim, Ki-Nam Moon, Chang Mo Kim, Seong-Eun Jung, Sung-Ae J Korean Med Sci Original Article BACKGROUND: Gender-related factors might play an important role in the development of reflux esophagitis (RE) and symptomatic gastro-esophageal reflux disease (GERD). We aimed to evaluate the prevalence and risk factors for RE and symptomatic GERD and determine whether gender specific differences exist. METHODS: This study was conducted on a health cohort consisting of 10,158 participants who underwent comprehensive health screening. Lifestyles and gastrointestinal symptoms were investigated using a self-reported structured questionnaire. Questionnaires about menstrual status were added for the women. RESULTS: The prevalence of RE in men was significantly higher than that in women (10.6% vs. 2.0%, P < 0.001); however, symptomatic GERD showed predominance in women (6.2% vs. 2.5%, P < 0.001). Although the prevalence of RE gradually increased with the duration of menopause stratified by decade (P = 0.007), that of symptomatic GERD rapidly increased across the menopausal transit in women. Apart from common risk factors of obesity and current smoking for RE, over 70 years of age in women and hiatal hernia and hypertriglyceridemia in men were significant risk factors. In symptomatic GERD, high somatization was a common risk factor. Excessive alcohol drinking was a significant risk factor in men, but not in women. CONCLUSION: This study showed a predominance of RE in men, but a predominance of symptomatic GERD in women. In women, dynamic increase in the prevalence of GERD is closely related to the menopause conditions and its duration. There are specific risk factors for RE and symptomatic GERD according to gender differences. The Korean Academy of Medical Sciences 2019-05-22 /pmc/articles/PMC6543060/ /pubmed/31144481 http://dx.doi.org/10.3346/jkms.2019.34.e158 Text en © 2019 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Sang Yoon
Jung, Hye-Kyung
Lim, Jiyoung
Kim, Tae Oh
Choe, A Reum
Tae, Chung Hyun
Shim, Ki-Nam
Moon, Chang Mo
Kim, Seong-Eun
Jung, Sung-Ae
Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease
title Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease
title_full Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease
title_fullStr Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease
title_full_unstemmed Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease
title_short Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease
title_sort gender specific differences in prevalence and risk factors for gastro-esophageal reflux disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543060/
https://www.ncbi.nlm.nih.gov/pubmed/31144481
http://dx.doi.org/10.3346/jkms.2019.34.e158
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