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Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease
BACKGROUND: Gender-related factors might play an important role in the development of reflux esophagitis (RE) and symptomatic gastro-esophageal reflux disease (GERD). We aimed to evaluate the prevalence and risk factors for RE and symptomatic GERD and determine whether gender specific differences ex...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543060/ https://www.ncbi.nlm.nih.gov/pubmed/31144481 http://dx.doi.org/10.3346/jkms.2019.34.e158 |
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author | Kim, Sang Yoon Jung, Hye-Kyung Lim, Jiyoung Kim, Tae Oh Choe, A Reum Tae, Chung Hyun Shim, Ki-Nam Moon, Chang Mo Kim, Seong-Eun Jung, Sung-Ae |
author_facet | Kim, Sang Yoon Jung, Hye-Kyung Lim, Jiyoung Kim, Tae Oh Choe, A Reum Tae, Chung Hyun Shim, Ki-Nam Moon, Chang Mo Kim, Seong-Eun Jung, Sung-Ae |
author_sort | Kim, Sang Yoon |
collection | PubMed |
description | BACKGROUND: Gender-related factors might play an important role in the development of reflux esophagitis (RE) and symptomatic gastro-esophageal reflux disease (GERD). We aimed to evaluate the prevalence and risk factors for RE and symptomatic GERD and determine whether gender specific differences exist. METHODS: This study was conducted on a health cohort consisting of 10,158 participants who underwent comprehensive health screening. Lifestyles and gastrointestinal symptoms were investigated using a self-reported structured questionnaire. Questionnaires about menstrual status were added for the women. RESULTS: The prevalence of RE in men was significantly higher than that in women (10.6% vs. 2.0%, P < 0.001); however, symptomatic GERD showed predominance in women (6.2% vs. 2.5%, P < 0.001). Although the prevalence of RE gradually increased with the duration of menopause stratified by decade (P = 0.007), that of symptomatic GERD rapidly increased across the menopausal transit in women. Apart from common risk factors of obesity and current smoking for RE, over 70 years of age in women and hiatal hernia and hypertriglyceridemia in men were significant risk factors. In symptomatic GERD, high somatization was a common risk factor. Excessive alcohol drinking was a significant risk factor in men, but not in women. CONCLUSION: This study showed a predominance of RE in men, but a predominance of symptomatic GERD in women. In women, dynamic increase in the prevalence of GERD is closely related to the menopause conditions and its duration. There are specific risk factors for RE and symptomatic GERD according to gender differences. |
format | Online Article Text |
id | pubmed-6543060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-65430602019-06-05 Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease Kim, Sang Yoon Jung, Hye-Kyung Lim, Jiyoung Kim, Tae Oh Choe, A Reum Tae, Chung Hyun Shim, Ki-Nam Moon, Chang Mo Kim, Seong-Eun Jung, Sung-Ae J Korean Med Sci Original Article BACKGROUND: Gender-related factors might play an important role in the development of reflux esophagitis (RE) and symptomatic gastro-esophageal reflux disease (GERD). We aimed to evaluate the prevalence and risk factors for RE and symptomatic GERD and determine whether gender specific differences exist. METHODS: This study was conducted on a health cohort consisting of 10,158 participants who underwent comprehensive health screening. Lifestyles and gastrointestinal symptoms were investigated using a self-reported structured questionnaire. Questionnaires about menstrual status were added for the women. RESULTS: The prevalence of RE in men was significantly higher than that in women (10.6% vs. 2.0%, P < 0.001); however, symptomatic GERD showed predominance in women (6.2% vs. 2.5%, P < 0.001). Although the prevalence of RE gradually increased with the duration of menopause stratified by decade (P = 0.007), that of symptomatic GERD rapidly increased across the menopausal transit in women. Apart from common risk factors of obesity and current smoking for RE, over 70 years of age in women and hiatal hernia and hypertriglyceridemia in men were significant risk factors. In symptomatic GERD, high somatization was a common risk factor. Excessive alcohol drinking was a significant risk factor in men, but not in women. CONCLUSION: This study showed a predominance of RE in men, but a predominance of symptomatic GERD in women. In women, dynamic increase in the prevalence of GERD is closely related to the menopause conditions and its duration. There are specific risk factors for RE and symptomatic GERD according to gender differences. The Korean Academy of Medical Sciences 2019-05-22 /pmc/articles/PMC6543060/ /pubmed/31144481 http://dx.doi.org/10.3346/jkms.2019.34.e158 Text en © 2019 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Sang Yoon Jung, Hye-Kyung Lim, Jiyoung Kim, Tae Oh Choe, A Reum Tae, Chung Hyun Shim, Ki-Nam Moon, Chang Mo Kim, Seong-Eun Jung, Sung-Ae Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease |
title | Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease |
title_full | Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease |
title_fullStr | Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease |
title_full_unstemmed | Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease |
title_short | Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease |
title_sort | gender specific differences in prevalence and risk factors for gastro-esophageal reflux disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543060/ https://www.ncbi.nlm.nih.gov/pubmed/31144481 http://dx.doi.org/10.3346/jkms.2019.34.e158 |
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