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Redox control of yeast Sir2 activity is involved in acetic acid resistance and longevity
Yeast Sir2 is an NAD-dependent histone deacetylase related to oxidative stress and aging. In a previous study, we showed that Sir2 is regulated by S-glutathionylation of key cysteine residues located at the catalytic domain. Mutation of these residues results in strains with increased resistance to...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543126/ https://www.ncbi.nlm.nih.gov/pubmed/31153040 http://dx.doi.org/10.1016/j.redox.2019.101229 |