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Achievement of Target Serum Uric Acid Levels and Factors Associated with Therapeutic Failure among Japanese Men Treated for Hyperuricemia/Gout

OBJECTIVE: To assess the rate of successfully achieving treatment goals among Japanese men with hyperuricemia/gout and identify factors influencing the success rate. METHODS: This cross-sectional study, conducted from January to December 2012, examined the serum uric acid (SUA) levels and clinical c...

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Autores principales: Katayama, Akiko, Yokokawa, Hirohide, Fukuda, Hiroshi, Ono, Yoshiki, Isonuma, Hiroshi, Hisaoka, Teruhiko, Naito, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543211/
https://www.ncbi.nlm.nih.gov/pubmed/30626825
http://dx.doi.org/10.2169/internalmedicine.1899-18
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author Katayama, Akiko
Yokokawa, Hirohide
Fukuda, Hiroshi
Ono, Yoshiki
Isonuma, Hiroshi
Hisaoka, Teruhiko
Naito, Toshio
author_facet Katayama, Akiko
Yokokawa, Hirohide
Fukuda, Hiroshi
Ono, Yoshiki
Isonuma, Hiroshi
Hisaoka, Teruhiko
Naito, Toshio
author_sort Katayama, Akiko
collection PubMed
description OBJECTIVE: To assess the rate of successfully achieving treatment goals among Japanese men with hyperuricemia/gout and identify factors influencing the success rate. METHODS: This cross-sectional study, conducted from January to December 2012, examined the serum uric acid (SUA) levels and clinical characteristics of 2,103 men with hyperuricemia/gout selected from an initial population of 136,770 individuals who participated in a workplace health checkup. The success rates (defined as SUA ≤6.0 mg/dL) were calculated, and a multivariate analysis was used to identify factors associated with “therapeutic failure” to achieve target SUA levels. RESULTS: The rate of successfully achieving the target SUA level was 37.5%. The body mass index (BMI) was significantly associated with therapeutic failure [25.0≤ Category (C)2<27.5, adjusted odds ratio (AOR) =1.35; 27.5≤C3<30.0, AOR=1.69; C4 ≥ 30.0, AOR=1.94; relative to C1<25.0]. A significant positive association was also observed between waist circumference (WC) and therapeutic failure (85≤C2<90, OR=1.29; 90≤C3<95, OR=1.41; 95≤C4, OR=2.28; relative to C1<85.0 cm). Those with higher BMI/WC measurements were significantly more likely to have higher SUA levels than those with lower such measurements. The ongoing intake of dyslipidemia medication was identified as a protective factor against therapeutic failure. DISCUSSION: Our findings suggest a possible association between obesity and therapeutic failure, underscoring the importance of maintaining lipid profiles as part of managing SUA levels. Better management of both obesity and dyslipidemia may prevent future cardiovascular disorders by ensuring healthier SUA levels.
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spelling pubmed-65432112019-06-03 Achievement of Target Serum Uric Acid Levels and Factors Associated with Therapeutic Failure among Japanese Men Treated for Hyperuricemia/Gout Katayama, Akiko Yokokawa, Hirohide Fukuda, Hiroshi Ono, Yoshiki Isonuma, Hiroshi Hisaoka, Teruhiko Naito, Toshio Intern Med Original Article OBJECTIVE: To assess the rate of successfully achieving treatment goals among Japanese men with hyperuricemia/gout and identify factors influencing the success rate. METHODS: This cross-sectional study, conducted from January to December 2012, examined the serum uric acid (SUA) levels and clinical characteristics of 2,103 men with hyperuricemia/gout selected from an initial population of 136,770 individuals who participated in a workplace health checkup. The success rates (defined as SUA ≤6.0 mg/dL) were calculated, and a multivariate analysis was used to identify factors associated with “therapeutic failure” to achieve target SUA levels. RESULTS: The rate of successfully achieving the target SUA level was 37.5%. The body mass index (BMI) was significantly associated with therapeutic failure [25.0≤ Category (C)2<27.5, adjusted odds ratio (AOR) =1.35; 27.5≤C3<30.0, AOR=1.69; C4 ≥ 30.0, AOR=1.94; relative to C1<25.0]. A significant positive association was also observed between waist circumference (WC) and therapeutic failure (85≤C2<90, OR=1.29; 90≤C3<95, OR=1.41; 95≤C4, OR=2.28; relative to C1<85.0 cm). Those with higher BMI/WC measurements were significantly more likely to have higher SUA levels than those with lower such measurements. The ongoing intake of dyslipidemia medication was identified as a protective factor against therapeutic failure. DISCUSSION: Our findings suggest a possible association between obesity and therapeutic failure, underscoring the importance of maintaining lipid profiles as part of managing SUA levels. Better management of both obesity and dyslipidemia may prevent future cardiovascular disorders by ensuring healthier SUA levels. The Japanese Society of Internal Medicine 2019-01-10 2019-05-01 /pmc/articles/PMC6543211/ /pubmed/30626825 http://dx.doi.org/10.2169/internalmedicine.1899-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Katayama, Akiko
Yokokawa, Hirohide
Fukuda, Hiroshi
Ono, Yoshiki
Isonuma, Hiroshi
Hisaoka, Teruhiko
Naito, Toshio
Achievement of Target Serum Uric Acid Levels and Factors Associated with Therapeutic Failure among Japanese Men Treated for Hyperuricemia/Gout
title Achievement of Target Serum Uric Acid Levels and Factors Associated with Therapeutic Failure among Japanese Men Treated for Hyperuricemia/Gout
title_full Achievement of Target Serum Uric Acid Levels and Factors Associated with Therapeutic Failure among Japanese Men Treated for Hyperuricemia/Gout
title_fullStr Achievement of Target Serum Uric Acid Levels and Factors Associated with Therapeutic Failure among Japanese Men Treated for Hyperuricemia/Gout
title_full_unstemmed Achievement of Target Serum Uric Acid Levels and Factors Associated with Therapeutic Failure among Japanese Men Treated for Hyperuricemia/Gout
title_short Achievement of Target Serum Uric Acid Levels and Factors Associated with Therapeutic Failure among Japanese Men Treated for Hyperuricemia/Gout
title_sort achievement of target serum uric acid levels and factors associated with therapeutic failure among japanese men treated for hyperuricemia/gout
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543211/
https://www.ncbi.nlm.nih.gov/pubmed/30626825
http://dx.doi.org/10.2169/internalmedicine.1899-18
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