Diffusion-weighted Whole-body Imaging with Background Body Signal Suppression (DWIBS) as a Novel Imaging Modality for Disease Activity Assessment in Takayasu's Arteritis

A 26-year-old woman with Takayasu's arteritis (TAK) experienced back and neck pain during tocilizumab (TCZ) treatment. The levels of C-reactive protein were normal, and ultrasonography revealed no significant changes. Diffusion-weighted whole-body imaging with background body signal suppression...

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Detalles Bibliográficos
Autores principales: Oguro, Eri, Ohshima, Shiro, Kikuchi-Taura, Akie, Murata, Atsuko, Kuzuya, Kentaro, Okita, Yasutaka, Matsuoka, Hidetoshi, Teshigawara, Satoru, Yoshimura, Maiko, Yoshida, Yuji, Isoda, Kentaro, Kudo-Tanaka, Eriko, Harada, Yoshinori, Kaminou, Toshio, Saeki, Yukihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543213/
https://www.ncbi.nlm.nih.gov/pubmed/30626815
http://dx.doi.org/10.2169/internalmedicine.1792-18
Descripción
Sumario:A 26-year-old woman with Takayasu's arteritis (TAK) experienced back and neck pain during tocilizumab (TCZ) treatment. The levels of C-reactive protein were normal, and ultrasonography revealed no significant changes. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) showed signal enhancement in the walls of several arteries. Contrast computed tomography showed arterial inflammation in the same lesion. After increasing the dose of prednisolone and TCZ, all signal enhancements decreased and continued to decrease, as observed on days 76 and 132. Thus, DWIBS may be a novel imaging modality for assessing the disease activity of TAK, particularly during follow-up.

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