Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung

Ewing's sarcoma (ES)/primitive neuroectodermal tumors (PNETs) are highly malignant neoplasms that usually affect the bones and soft tissues in children and young adults. ES/PNET of the lung is very rare and is associated with a poor prognosis. We herein report a case of ES/PNET of the left lung...

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Autores principales: Takigami, Ayako, Yamasawa, Hideaki, Kurosaki, Ayako, Sakamoto, Noritaka, Onuki, Tsugitoshi, Mato, Naoko, Tetsuka, Kenji, Endo, Shunsuke, Niki, Toshiro, Bando, Masashi, Hagiwara, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543224/
https://www.ncbi.nlm.nih.gov/pubmed/30626819
http://dx.doi.org/10.2169/internalmedicine.1549-18
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author Takigami, Ayako
Yamasawa, Hideaki
Kurosaki, Ayako
Sakamoto, Noritaka
Onuki, Tsugitoshi
Mato, Naoko
Tetsuka, Kenji
Endo, Shunsuke
Niki, Toshiro
Bando, Masashi
Hagiwara, Koichi
author_facet Takigami, Ayako
Yamasawa, Hideaki
Kurosaki, Ayako
Sakamoto, Noritaka
Onuki, Tsugitoshi
Mato, Naoko
Tetsuka, Kenji
Endo, Shunsuke
Niki, Toshiro
Bando, Masashi
Hagiwara, Koichi
author_sort Takigami, Ayako
collection PubMed
description Ewing's sarcoma (ES)/primitive neuroectodermal tumors (PNETs) are highly malignant neoplasms that usually affect the bones and soft tissues in children and young adults. ES/PNET of the lung is very rare and is associated with a poor prognosis. We herein report a case of ES/PNET of the left lung in a 45-year-old man. He was treated with neoadjuvant chemotherapy and pneumonectomy, but unfortunately his disease recurred 1.5 months after surgery. He was started on pazopanib, which resulted in a five-month progression-free survival. To our knowledge, this is the first demonstration of pazopanib efficacy in ES/PNET of the lung.
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spelling pubmed-65432242019-06-03 Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung Takigami, Ayako Yamasawa, Hideaki Kurosaki, Ayako Sakamoto, Noritaka Onuki, Tsugitoshi Mato, Naoko Tetsuka, Kenji Endo, Shunsuke Niki, Toshiro Bando, Masashi Hagiwara, Koichi Intern Med Case Report Ewing's sarcoma (ES)/primitive neuroectodermal tumors (PNETs) are highly malignant neoplasms that usually affect the bones and soft tissues in children and young adults. ES/PNET of the lung is very rare and is associated with a poor prognosis. We herein report a case of ES/PNET of the left lung in a 45-year-old man. He was treated with neoadjuvant chemotherapy and pneumonectomy, but unfortunately his disease recurred 1.5 months after surgery. He was started on pazopanib, which resulted in a five-month progression-free survival. To our knowledge, this is the first demonstration of pazopanib efficacy in ES/PNET of the lung. The Japanese Society of Internal Medicine 2019-01-10 2019-05-01 /pmc/articles/PMC6543224/ /pubmed/30626819 http://dx.doi.org/10.2169/internalmedicine.1549-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takigami, Ayako
Yamasawa, Hideaki
Kurosaki, Ayako
Sakamoto, Noritaka
Onuki, Tsugitoshi
Mato, Naoko
Tetsuka, Kenji
Endo, Shunsuke
Niki, Toshiro
Bando, Masashi
Hagiwara, Koichi
Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung
title Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung
title_full Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung
title_fullStr Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung
title_full_unstemmed Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung
title_short Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung
title_sort pazopanib confers a progression-free survival in a patient with ewing's sarcoma/primitive neuroectodermal tumor of the lung
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543224/
https://www.ncbi.nlm.nih.gov/pubmed/30626819
http://dx.doi.org/10.2169/internalmedicine.1549-18
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