Clinical Trial: CYP2D6 Related Dose Escalation of Tamoxifen in Breast Cancer Patients With Iranian Ethnic Background Resulted in Increased Concentrations of Tamoxifen and Its Metabolites

Introduction: The polymorphic enzyme cytochrome P450 2D6 (CYP2D6) catalyzes a major step in the bioactivation of tamoxifen. Genotyping of clinically relevant CYP2D6 alleles and subsequent dose adjustment is a promising approach to individualize breast cancer therapy. The aim of this study was to inv...

Descripción completa

Detalles Bibliográficos
Autores principales: Khalaj, Zahra, Baratieh, Zohreh, Nikpour, Parvaneh, Schwab, Matthias, Schaeffeler, Elke, Mokarian, Fariborz, Khanahmad, Hossein, Salehi, Rasoul, Mürdter, Thomas E., Salehi, Mansoor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543868/
https://www.ncbi.nlm.nih.gov/pubmed/31178724
http://dx.doi.org/10.3389/fphar.2019.00530

Ejemplares similares

Ejemplares similares