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Impact of Home-to-Centre Distance on Bone Marrow Transplantation Outcomes

OBJECTIVES: Haematopoietic stem cell transplantation (HSCT) in Oman started in 1994 at Sultan Qaboos University Hospital (SQUH), Muscat, Oman. Previous studies have suggested that longer driving time to the transplant centre (DTC) independently correlates with worse overall survival (OS). Therefore,...

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Autores principales: Al Naabi, Malak, Al Khabori, Murtadha, Al-Huneini, Mohammed, Al-Rawas, Abdulhakeem, Dennison, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544071/
https://www.ncbi.nlm.nih.gov/pubmed/31198590
http://dx.doi.org/10.18295/squmj.2019.19.01.004
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author Al Naabi, Malak
Al Khabori, Murtadha
Al-Huneini, Mohammed
Al-Rawas, Abdulhakeem
Dennison, David
author_facet Al Naabi, Malak
Al Khabori, Murtadha
Al-Huneini, Mohammed
Al-Rawas, Abdulhakeem
Dennison, David
author_sort Al Naabi, Malak
collection PubMed
description OBJECTIVES: Haematopoietic stem cell transplantation (HSCT) in Oman started in 1994 at Sultan Qaboos University Hospital (SQUH), Muscat, Oman. Previous studies have suggested that longer driving time to the transplant centre (DTC) independently correlates with worse overall survival (OS). Therefore, this study aimed to examine the impact of DTC on OS and acute graft-versus-host disease (aGvHD). METHODS: This retrospective study included all patients who underwent HSCT between February 2006 and December 2016 at SQUH. The DTC was determined using Google Maps (Google LLC., Mountain View, California, USA). The probability of OS was estimated using a Kaplan-Meier estimator and the impact of DTC on OS was compared using a Cox model. RESULTS: A total of 170 patients were included in this study of which 52% were male and 28% were from the Al Batinah region. The mean age was 14.2 ± 12.2 years. The mean haemoglobin, platelet and white blood cell counts before the HSCT were 10.3 ± 1.7 g/dL, 207 ± 131 × 10(9)/L and 5.1 ± 5.9 × 10(9)/L, respectively. The median DTC for those with aGvHD was 84 minutes, which is similar to patients without aGvHD (P = 0.918). The hazard ratio for DTC as a predictor of OS was 1.0 (P = 0.901). CONCLUSION: In this single centre study, DTC did not impact aGvHD or OS in patients post-HSCT. The study was limited by its retrospective design and the small sample size. It is recommended that these results be confirmed in a prospective study.
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spelling pubmed-65440712019-06-13 Impact of Home-to-Centre Distance on Bone Marrow Transplantation Outcomes Al Naabi, Malak Al Khabori, Murtadha Al-Huneini, Mohammed Al-Rawas, Abdulhakeem Dennison, David Sultan Qaboos Univ Med J Clinical & Basic Research OBJECTIVES: Haematopoietic stem cell transplantation (HSCT) in Oman started in 1994 at Sultan Qaboos University Hospital (SQUH), Muscat, Oman. Previous studies have suggested that longer driving time to the transplant centre (DTC) independently correlates with worse overall survival (OS). Therefore, this study aimed to examine the impact of DTC on OS and acute graft-versus-host disease (aGvHD). METHODS: This retrospective study included all patients who underwent HSCT between February 2006 and December 2016 at SQUH. The DTC was determined using Google Maps (Google LLC., Mountain View, California, USA). The probability of OS was estimated using a Kaplan-Meier estimator and the impact of DTC on OS was compared using a Cox model. RESULTS: A total of 170 patients were included in this study of which 52% were male and 28% were from the Al Batinah region. The mean age was 14.2 ± 12.2 years. The mean haemoglobin, platelet and white blood cell counts before the HSCT were 10.3 ± 1.7 g/dL, 207 ± 131 × 10(9)/L and 5.1 ± 5.9 × 10(9)/L, respectively. The median DTC for those with aGvHD was 84 minutes, which is similar to patients without aGvHD (P = 0.918). The hazard ratio for DTC as a predictor of OS was 1.0 (P = 0.901). CONCLUSION: In this single centre study, DTC did not impact aGvHD or OS in patients post-HSCT. The study was limited by its retrospective design and the small sample size. It is recommended that these results be confirmed in a prospective study. Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences 2019-02 2019-05-30 /pmc/articles/PMC6544071/ /pubmed/31198590 http://dx.doi.org/10.18295/squmj.2019.19.01.004 Text en © Copyright 2019, Sultan Qaboos University Medical Journal, All Rights Reserved This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nd/4.0/) .
spellingShingle Clinical & Basic Research
Al Naabi, Malak
Al Khabori, Murtadha
Al-Huneini, Mohammed
Al-Rawas, Abdulhakeem
Dennison, David
Impact of Home-to-Centre Distance on Bone Marrow Transplantation Outcomes
title Impact of Home-to-Centre Distance on Bone Marrow Transplantation Outcomes
title_full Impact of Home-to-Centre Distance on Bone Marrow Transplantation Outcomes
title_fullStr Impact of Home-to-Centre Distance on Bone Marrow Transplantation Outcomes
title_full_unstemmed Impact of Home-to-Centre Distance on Bone Marrow Transplantation Outcomes
title_short Impact of Home-to-Centre Distance on Bone Marrow Transplantation Outcomes
title_sort impact of home-to-centre distance on bone marrow transplantation outcomes
topic Clinical & Basic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544071/
https://www.ncbi.nlm.nih.gov/pubmed/31198590
http://dx.doi.org/10.18295/squmj.2019.19.01.004
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