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Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae

Unbiased screening of large randomized chemical libraries in vivo is a powerful tool to find new drugs and targets. However, forward chemical screens in zebrafish can be time consuming and usually >99% of test compounds have no significant effect on the desired phenotype. Here, we sought to find...

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Detalles Bibliográficos
Autores principales: Ohnesorge, Nils, Sasore, Temitope, Hillary, Daniel, Alvarez, Yolanda, Carey, Michelle, Kennedy, Breandán N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544088/
https://www.ncbi.nlm.nih.gov/pubmed/31178719
http://dx.doi.org/10.3389/fphar.2019.00508