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Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae

Unbiased screening of large randomized chemical libraries in vivo is a powerful tool to find new drugs and targets. However, forward chemical screens in zebrafish can be time consuming and usually >99% of test compounds have no significant effect on the desired phenotype. Here, we sought to find...

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Detalles Bibliográficos
Autores principales:	Ohnesorge, Nils, Sasore, Temitope, Hillary, Daniel, Alvarez, Yolanda, Carey, Michelle, Kennedy, Breandán N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544088/ https://www.ncbi.nlm.nih.gov/pubmed/31178719 http://dx.doi.org/10.3389/fphar.2019.00508

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