Hydroxy group-enabled highly regio- and stereo-selective hydrocarboxylation of alkynes

Here we present an example of utilizing hydroxy groups for regioselectivity control in the addition reaction of alkynes—a highly efficient Pd-catalyzed syn-hydrocarboxylation of readily available 2-alkynylic alcohols with CO in the presence of alcohols with an unprecedented regioselectivity affordin...

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Detalles Bibliográficos
Autores principales: Huang, Chaofan, Qian, Hui, Zhang, Wanli, Ma, Shengming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544123/
https://www.ncbi.nlm.nih.gov/pubmed/31293734
http://dx.doi.org/10.1039/c8sc05743e
Descripción
Sumario:Here we present an example of utilizing hydroxy groups for regioselectivity control in the addition reaction of alkynes—a highly efficient Pd-catalyzed syn-hydrocarboxylation of readily available 2-alkynylic alcohols with CO in the presence of alcohols with an unprecedented regioselectivity affording 3-hydroxy-2(E)-alkenoates. The role of the hydroxy group has been carefully studied. The synthetic potential of the products has also been demonstrated.

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