Determination of Viscoelastic Properties of human Carotid Atherosclerotic Plaque by Inverse Boundary Value Analysis

In this study, we assessed the mechanical response of samples from human atherosclerotic diseased media and fibrous cap via uniaxial tensile testing. Results show a pronounced hysteresis phenomenon caused by viscoelasticity during the loading-unloading process. An inverse analysis method with finite...

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Detalles Bibliográficos
Autores principales: Leng, Xiaochang, Zhou, Boran, Deng, Xiaomin, Davis, Lindsey, Sutton, Michael A., Shazly, Tarek, Lessner, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544144/
https://www.ncbi.nlm.nih.gov/pubmed/31156719
http://dx.doi.org/10.1088/1757-899X/381/1/012171
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author Leng, Xiaochang
Zhou, Boran
Deng, Xiaomin
Davis, Lindsey
Sutton, Michael A.
Shazly, Tarek
Lessner, Susan M.
author_facet Leng, Xiaochang
Zhou, Boran
Deng, Xiaomin
Davis, Lindsey
Sutton, Michael A.
Shazly, Tarek
Lessner, Susan M.
author_sort Leng, Xiaochang
collection PubMed
description In this study, we assessed the mechanical response of samples from human atherosclerotic diseased media and fibrous cap via uniaxial tensile testing. Results show a pronounced hysteresis phenomenon caused by viscoelasticity during the loading-unloading process. An inverse analysis method with finite element modeling was employed to identify the material parameter values for a viscoelastic anisotropic (VA) constitutive model through matching simulation predictions of load-displacement curves with experimental measurements. The identified material parameter values can be used in simulation studies of diseased human carotid arteries, including investigations of inflation processes associated with stenting or angioplasty.
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spelling pubmed-65441442019-05-31 Determination of Viscoelastic Properties of human Carotid Atherosclerotic Plaque by Inverse Boundary Value Analysis Leng, Xiaochang Zhou, Boran Deng, Xiaomin Davis, Lindsey Sutton, Michael A. Shazly, Tarek Lessner, Susan M. IOP Conf Ser Mater Sci Eng Article In this study, we assessed the mechanical response of samples from human atherosclerotic diseased media and fibrous cap via uniaxial tensile testing. Results show a pronounced hysteresis phenomenon caused by viscoelasticity during the loading-unloading process. An inverse analysis method with finite element modeling was employed to identify the material parameter values for a viscoelastic anisotropic (VA) constitutive model through matching simulation predictions of load-displacement curves with experimental measurements. The identified material parameter values can be used in simulation studies of diseased human carotid arteries, including investigations of inflation processes associated with stenting or angioplasty. 2018-08-16 2018 /pmc/articles/PMC6544144/ /pubmed/31156719 http://dx.doi.org/10.1088/1757-899X/381/1/012171 Text en http://creativecommons.org/licenses/by-nc/4.0/ Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
spellingShingle Article
Leng, Xiaochang
Zhou, Boran
Deng, Xiaomin
Davis, Lindsey
Sutton, Michael A.
Shazly, Tarek
Lessner, Susan M.
Determination of Viscoelastic Properties of human Carotid Atherosclerotic Plaque by Inverse Boundary Value Analysis
title Determination of Viscoelastic Properties of human Carotid Atherosclerotic Plaque by Inverse Boundary Value Analysis
title_full Determination of Viscoelastic Properties of human Carotid Atherosclerotic Plaque by Inverse Boundary Value Analysis
title_fullStr Determination of Viscoelastic Properties of human Carotid Atherosclerotic Plaque by Inverse Boundary Value Analysis
title_full_unstemmed Determination of Viscoelastic Properties of human Carotid Atherosclerotic Plaque by Inverse Boundary Value Analysis
title_short Determination of Viscoelastic Properties of human Carotid Atherosclerotic Plaque by Inverse Boundary Value Analysis
title_sort determination of viscoelastic properties of human carotid atherosclerotic plaque by inverse boundary value analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544144/
https://www.ncbi.nlm.nih.gov/pubmed/31156719
http://dx.doi.org/10.1088/1757-899X/381/1/012171
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