Development and validation of a multiplex UHPLC-MS/MS method for the determination of the investigational antibiotic against multi-resistant tuberculosis macozinone (PBTZ169) and five active metabolites in human plasma

The emergence of Mycobacterium tuberculosis strains resistant to current first-line antibiotic regimens constitutes a major global health threat. New treatments against multidrug-resistant tuberculosis (MDR-TB) are thus eagerly needed in particular in countries with a high MDR-TB prevalence. In this...

Descripción completa

Detalles Bibliográficos
Autores principales: Spaggiari, Dany, Desfontaine, Vincent, Cruchon, Sandra, Guinchard, Sylvie, Vocat, Anthony, Blattes, Emilyne, Pitteloud, Jeff, Ciullini, Lorenzo, Bardinet, Carine, Ivanyuk, Anton, Makarov, Vadim, Ryabova, Olga, Buclin, Thierry, Cole, Stewart T., Decosterd, Laurent A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544242/
https://www.ncbi.nlm.nih.gov/pubmed/31150423
http://dx.doi.org/10.1371/journal.pone.0217139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544242/
https://www.ncbi.nlm.nih.gov/pubmed/31150423
http://dx.doi.org/10.1371/journal.pone.0217139

Ejemplares similares