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Optoacoustic properties of Doxorubicin – A pilot study
Doxorubicin (DOX) is a widely used chemotherapeutic anticancer drug. Its intrinsic fluorescence properties enable investigation of tumor response, drug distribution and metabolism. First phantom studies in vitro showed optoacoustic property of DOX. We therefore aimed to further investigate the optoa...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544257/ https://www.ncbi.nlm.nih.gov/pubmed/31150471 http://dx.doi.org/10.1371/journal.pone.0217576 |
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author | Kimm, Melanie A. Gross, Claudia Déan-Ben, Xose Luis Ron, Avihai Rummeny, Ernst J. Lin, Hsiao-Chun Amy Höltke, Carsten Razansky, Daniel Wildgruber, Moritz |
author_facet | Kimm, Melanie A. Gross, Claudia Déan-Ben, Xose Luis Ron, Avihai Rummeny, Ernst J. Lin, Hsiao-Chun Amy Höltke, Carsten Razansky, Daniel Wildgruber, Moritz |
author_sort | Kimm, Melanie A. |
collection | PubMed |
description | Doxorubicin (DOX) is a widely used chemotherapeutic anticancer drug. Its intrinsic fluorescence properties enable investigation of tumor response, drug distribution and metabolism. First phantom studies in vitro showed optoacoustic property of DOX. We therefore aimed to further investigate the optoacoustic properties of DOX in biological tissue in order to explore its potential as theranostic agent. We analysed doxorubicin hydrochloride (Dox·HCl) and liposomal encapsulated doxorubicin hydrochloride (Dox·Lipo), two common drugs for anti-cancer treatment in clinical medicine. Optoacoustic measurements revealed a strong signal of both doxorubicin substrates at 488 nm excitation wavelength. Post mortem analysis of intra-tumoral injections of DOX revealed a detectable optoacoustic signal even at three days after the injection. We thereby demonstrate the general feasibility of doxorubicin detection in biological tissue by means of optoacoustic tomography, which could be applied for high resolution imaging at mesoscopic depths dictated by effective penetration of visible light into the biological tissues. |
format | Online Article Text |
id | pubmed-6544257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-65442572019-06-17 Optoacoustic properties of Doxorubicin – A pilot study Kimm, Melanie A. Gross, Claudia Déan-Ben, Xose Luis Ron, Avihai Rummeny, Ernst J. Lin, Hsiao-Chun Amy Höltke, Carsten Razansky, Daniel Wildgruber, Moritz PLoS One Research Article Doxorubicin (DOX) is a widely used chemotherapeutic anticancer drug. Its intrinsic fluorescence properties enable investigation of tumor response, drug distribution and metabolism. First phantom studies in vitro showed optoacoustic property of DOX. We therefore aimed to further investigate the optoacoustic properties of DOX in biological tissue in order to explore its potential as theranostic agent. We analysed doxorubicin hydrochloride (Dox·HCl) and liposomal encapsulated doxorubicin hydrochloride (Dox·Lipo), two common drugs for anti-cancer treatment in clinical medicine. Optoacoustic measurements revealed a strong signal of both doxorubicin substrates at 488 nm excitation wavelength. Post mortem analysis of intra-tumoral injections of DOX revealed a detectable optoacoustic signal even at three days after the injection. We thereby demonstrate the general feasibility of doxorubicin detection in biological tissue by means of optoacoustic tomography, which could be applied for high resolution imaging at mesoscopic depths dictated by effective penetration of visible light into the biological tissues. Public Library of Science 2019-05-31 /pmc/articles/PMC6544257/ /pubmed/31150471 http://dx.doi.org/10.1371/journal.pone.0217576 Text en © 2019 Kimm et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kimm, Melanie A. Gross, Claudia Déan-Ben, Xose Luis Ron, Avihai Rummeny, Ernst J. Lin, Hsiao-Chun Amy Höltke, Carsten Razansky, Daniel Wildgruber, Moritz Optoacoustic properties of Doxorubicin – A pilot study |
title | Optoacoustic properties of Doxorubicin – A pilot study |
title_full | Optoacoustic properties of Doxorubicin – A pilot study |
title_fullStr | Optoacoustic properties of Doxorubicin – A pilot study |
title_full_unstemmed | Optoacoustic properties of Doxorubicin – A pilot study |
title_short | Optoacoustic properties of Doxorubicin – A pilot study |
title_sort | optoacoustic properties of doxorubicin – a pilot study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544257/ https://www.ncbi.nlm.nih.gov/pubmed/31150471 http://dx.doi.org/10.1371/journal.pone.0217576 |
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