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Optoacoustic properties of Doxorubicin – A pilot study

Doxorubicin (DOX) is a widely used chemotherapeutic anticancer drug. Its intrinsic fluorescence properties enable investigation of tumor response, drug distribution and metabolism. First phantom studies in vitro showed optoacoustic property of DOX. We therefore aimed to further investigate the optoa...

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Autores principales: Kimm, Melanie A., Gross, Claudia, Déan-Ben, Xose Luis, Ron, Avihai, Rummeny, Ernst J., Lin, Hsiao-Chun Amy, Höltke, Carsten, Razansky, Daniel, Wildgruber, Moritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544257/
https://www.ncbi.nlm.nih.gov/pubmed/31150471
http://dx.doi.org/10.1371/journal.pone.0217576
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author Kimm, Melanie A.
Gross, Claudia
Déan-Ben, Xose Luis
Ron, Avihai
Rummeny, Ernst J.
Lin, Hsiao-Chun Amy
Höltke, Carsten
Razansky, Daniel
Wildgruber, Moritz
author_facet Kimm, Melanie A.
Gross, Claudia
Déan-Ben, Xose Luis
Ron, Avihai
Rummeny, Ernst J.
Lin, Hsiao-Chun Amy
Höltke, Carsten
Razansky, Daniel
Wildgruber, Moritz
author_sort Kimm, Melanie A.
collection PubMed
description Doxorubicin (DOX) is a widely used chemotherapeutic anticancer drug. Its intrinsic fluorescence properties enable investigation of tumor response, drug distribution and metabolism. First phantom studies in vitro showed optoacoustic property of DOX. We therefore aimed to further investigate the optoacoustic properties of DOX in biological tissue in order to explore its potential as theranostic agent. We analysed doxorubicin hydrochloride (Dox·HCl) and liposomal encapsulated doxorubicin hydrochloride (Dox·Lipo), two common drugs for anti-cancer treatment in clinical medicine. Optoacoustic measurements revealed a strong signal of both doxorubicin substrates at 488 nm excitation wavelength. Post mortem analysis of intra-tumoral injections of DOX revealed a detectable optoacoustic signal even at three days after the injection. We thereby demonstrate the general feasibility of doxorubicin detection in biological tissue by means of optoacoustic tomography, which could be applied for high resolution imaging at mesoscopic depths dictated by effective penetration of visible light into the biological tissues.
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spelling pubmed-65442572019-06-17 Optoacoustic properties of Doxorubicin – A pilot study Kimm, Melanie A. Gross, Claudia Déan-Ben, Xose Luis Ron, Avihai Rummeny, Ernst J. Lin, Hsiao-Chun Amy Höltke, Carsten Razansky, Daniel Wildgruber, Moritz PLoS One Research Article Doxorubicin (DOX) is a widely used chemotherapeutic anticancer drug. Its intrinsic fluorescence properties enable investigation of tumor response, drug distribution and metabolism. First phantom studies in vitro showed optoacoustic property of DOX. We therefore aimed to further investigate the optoacoustic properties of DOX in biological tissue in order to explore its potential as theranostic agent. We analysed doxorubicin hydrochloride (Dox·HCl) and liposomal encapsulated doxorubicin hydrochloride (Dox·Lipo), two common drugs for anti-cancer treatment in clinical medicine. Optoacoustic measurements revealed a strong signal of both doxorubicin substrates at 488 nm excitation wavelength. Post mortem analysis of intra-tumoral injections of DOX revealed a detectable optoacoustic signal even at three days after the injection. We thereby demonstrate the general feasibility of doxorubicin detection in biological tissue by means of optoacoustic tomography, which could be applied for high resolution imaging at mesoscopic depths dictated by effective penetration of visible light into the biological tissues. Public Library of Science 2019-05-31 /pmc/articles/PMC6544257/ /pubmed/31150471 http://dx.doi.org/10.1371/journal.pone.0217576 Text en © 2019 Kimm et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kimm, Melanie A.
Gross, Claudia
Déan-Ben, Xose Luis
Ron, Avihai
Rummeny, Ernst J.
Lin, Hsiao-Chun Amy
Höltke, Carsten
Razansky, Daniel
Wildgruber, Moritz
Optoacoustic properties of Doxorubicin – A pilot study
title Optoacoustic properties of Doxorubicin – A pilot study
title_full Optoacoustic properties of Doxorubicin – A pilot study
title_fullStr Optoacoustic properties of Doxorubicin – A pilot study
title_full_unstemmed Optoacoustic properties of Doxorubicin – A pilot study
title_short Optoacoustic properties of Doxorubicin – A pilot study
title_sort optoacoustic properties of doxorubicin – a pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544257/
https://www.ncbi.nlm.nih.gov/pubmed/31150471
http://dx.doi.org/10.1371/journal.pone.0217576
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