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Pharmacokinetic parameters and mechanism of action of an efficient anti-Aβ single chain antibody fragment
The success of the targeting of amyloid-β (Aβ) oligomers through immunotherapy in Alzheimer’s disease (AD) mouse models has not been translated into the clinics. The use of single-chain variable fragments (scFvs) has been proposed to prevent the potential severe effects of full-length mAbs by preclu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544282/ https://www.ncbi.nlm.nih.gov/pubmed/31150495 http://dx.doi.org/10.1371/journal.pone.0217793 |