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Feasibility of measuring spleen stiffness with MR elastography and splenic volume to predict hepatic fibrosis stage
AIM: The aim of this study was to investigate the relationship between spleen stiffness value, splenic volume and the liver fibrosis stages. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board of our institute. We enrolled 109 patients that had undergone ab...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544288/ https://www.ncbi.nlm.nih.gov/pubmed/31150508 http://dx.doi.org/10.1371/journal.pone.0217876 |
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author | Cheng, Yi-Wen Chang, Ya-Chien Chen, Yao-Li Chen, Ran-Chou Chou, Chen-Te |
author_facet | Cheng, Yi-Wen Chang, Ya-Chien Chen, Yao-Li Chen, Ran-Chou Chou, Chen-Te |
author_sort | Cheng, Yi-Wen |
collection | PubMed |
description | AIM: The aim of this study was to investigate the relationship between spleen stiffness value, splenic volume and the liver fibrosis stages. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board of our institute. We enrolled 109 patients that had undergone abdominal MR imaging and histopathological examination. The preoperative MR imaging, MR elastography and laboratory data were reviewed. Liver stiffness and spleen stiffness were determined with MR elastography, and splenic volume was calculated. Liver fibrosis stage was determined using surgical pathology. RESULTS: The correlation coefficient between the liver stiffness and the fibrosis stage was r = 0.72 and r = 0.62 when the passive driver was on right chest wall and the left chest wall, respectively. The correlation coefficient between the spleen stiffness and the fibrosis stage was r = 0.63 and r = 0.18 when the passive driver was on the left chest wall and the right chest wall, respectively. The correlation coefficient between the splenic volume and the fibrosis stage was r = 0.31. The diagnostic performance of spleen stiffness was similar to liver stiffness in prediction of advanced liver fibrosis. The combination of spleen stiffness and liver stiffness provided greater sensitivity in prediction of advanced fibrosis than spleen or liver stiffness alone, but no significant difference was found. CONCLUSION: According to our study, the spleen stiffness value was useful in staging liver fibrosis. The combination of spleen stiffness and liver stiffness could provide higher diagnostic sensitivity than liver stiffness alone in prediction of advanced fibrosis. |
format | Online Article Text |
id | pubmed-6544288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-65442882019-06-17 Feasibility of measuring spleen stiffness with MR elastography and splenic volume to predict hepatic fibrosis stage Cheng, Yi-Wen Chang, Ya-Chien Chen, Yao-Li Chen, Ran-Chou Chou, Chen-Te PLoS One Research Article AIM: The aim of this study was to investigate the relationship between spleen stiffness value, splenic volume and the liver fibrosis stages. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board of our institute. We enrolled 109 patients that had undergone abdominal MR imaging and histopathological examination. The preoperative MR imaging, MR elastography and laboratory data were reviewed. Liver stiffness and spleen stiffness were determined with MR elastography, and splenic volume was calculated. Liver fibrosis stage was determined using surgical pathology. RESULTS: The correlation coefficient between the liver stiffness and the fibrosis stage was r = 0.72 and r = 0.62 when the passive driver was on right chest wall and the left chest wall, respectively. The correlation coefficient between the spleen stiffness and the fibrosis stage was r = 0.63 and r = 0.18 when the passive driver was on the left chest wall and the right chest wall, respectively. The correlation coefficient between the splenic volume and the fibrosis stage was r = 0.31. The diagnostic performance of spleen stiffness was similar to liver stiffness in prediction of advanced liver fibrosis. The combination of spleen stiffness and liver stiffness provided greater sensitivity in prediction of advanced fibrosis than spleen or liver stiffness alone, but no significant difference was found. CONCLUSION: According to our study, the spleen stiffness value was useful in staging liver fibrosis. The combination of spleen stiffness and liver stiffness could provide higher diagnostic sensitivity than liver stiffness alone in prediction of advanced fibrosis. Public Library of Science 2019-05-31 /pmc/articles/PMC6544288/ /pubmed/31150508 http://dx.doi.org/10.1371/journal.pone.0217876 Text en © 2019 Cheng et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Cheng, Yi-Wen Chang, Ya-Chien Chen, Yao-Li Chen, Ran-Chou Chou, Chen-Te Feasibility of measuring spleen stiffness with MR elastography and splenic volume to predict hepatic fibrosis stage |
title | Feasibility of measuring spleen stiffness with MR elastography and splenic volume to predict hepatic fibrosis stage |
title_full | Feasibility of measuring spleen stiffness with MR elastography and splenic volume to predict hepatic fibrosis stage |
title_fullStr | Feasibility of measuring spleen stiffness with MR elastography and splenic volume to predict hepatic fibrosis stage |
title_full_unstemmed | Feasibility of measuring spleen stiffness with MR elastography and splenic volume to predict hepatic fibrosis stage |
title_short | Feasibility of measuring spleen stiffness with MR elastography and splenic volume to predict hepatic fibrosis stage |
title_sort | feasibility of measuring spleen stiffness with mr elastography and splenic volume to predict hepatic fibrosis stage |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544288/ https://www.ncbi.nlm.nih.gov/pubmed/31150508 http://dx.doi.org/10.1371/journal.pone.0217876 |
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