The histone deacetylase inhibitor Romidepsin induces as a cascade of differential gene expression and altered histone H3K9 marks in myeloid leukaemia cells

Myelodysplastic syndromes (MDS) are a heterogeneous, clonal haematopoietic disorder, with ~1/3 of patients progressing to acute myeloid leukaemia (AML). Many elderly MDS patients do not tolerate intensive therapeutic regimens, and therefore have an unmet need for better tolerated therapies. Epigenet...

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Detalles Bibliográficos
Autores principales: Clarke, Kathryn, Young, Christine, Liberante, Fabio, McMullin, Mary-Frances, Thompson, Alexander, Mills, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544403/
https://www.ncbi.nlm.nih.gov/pubmed/31191819
http://dx.doi.org/10.18632/oncotarget.26877

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