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Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators
We demonstrate that combined treatment with metformin (Met) or its mitochondria-targeted analog, mito-metformin (Mito-Met), and various iron chelators synergistically inhibits proliferation of pancreatic and triple-negative breast cancer cells. Previously, we reported that Met (at millimolar levels)...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544408/ https://www.ncbi.nlm.nih.gov/pubmed/31191823 http://dx.doi.org/10.18632/oncotarget.26943 |