IFNγ induces epigenetic programming of human T-bet(hi) B cells and promotes TLR7/8 and IL-21 induced differentiation

Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse models, the role for IFNγ signaling in human antibody responses is unknown. We show that elevated levels of IFNγ in SLE patients correlate wit...

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Detalles Bibliográficos
Autores principales: Zumaquero, Esther, Stone, Sara L, Scharer, Christopher D, Jenks, Scott A, Nellore, Anoma, Mousseau, Betty, Rosal-Vela, Antonio, Botta, Davide, Bradley, John E, Wojciechowski, Wojciech, Ptacek, Travis, Danila, Maria I, Edberg, Jeffrey C, Bridges, S Louis, Kimberly, Robert P, Chatham, W Winn, Schoeb, Trenton R, Rosenberg, Alexander F, Boss, Jeremy M, Sanz, Ignacio, Lund, Frances E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544433/
https://www.ncbi.nlm.nih.gov/pubmed/31090539
http://dx.doi.org/10.7554/eLife.41641

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