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Context-dependent signaling of coincident auditory and visual events in primary visual cortex

Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant fe...

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Autores principales: Deneux, Thomas, Harrell, Evan R, Kempf, Alexandre, Ceballo, Sebastian, Filipchuk, Anton, Bathellier, Brice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544434/
https://www.ncbi.nlm.nih.gov/pubmed/31115334
http://dx.doi.org/10.7554/eLife.44006
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author Deneux, Thomas
Harrell, Evan R
Kempf, Alexandre
Ceballo, Sebastian
Filipchuk, Anton
Bathellier, Brice
author_facet Deneux, Thomas
Harrell, Evan R
Kempf, Alexandre
Ceballo, Sebastian
Filipchuk, Anton
Bathellier, Brice
author_sort Deneux, Thomas
collection PubMed
description Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant feature coded by the auditory cortex neurons projecting to primary visual cortex (V1). In V1, a small number of layer 1 interneurons gates this cross-modal information flow in a context-dependent manner. In dark conditions, auditory cortex inputs lead to suppression of the V1 population. However, when sound input coincides with a visual stimulus, visual responses are boosted in V1, most strongly after loud sound onsets. Thus, a dynamic, asymmetric circuit connecting AC and V1 contributes to the encoding of visual events that are coincident with sounds.
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spelling pubmed-65444342019-06-12 Context-dependent signaling of coincident auditory and visual events in primary visual cortex Deneux, Thomas Harrell, Evan R Kempf, Alexandre Ceballo, Sebastian Filipchuk, Anton Bathellier, Brice eLife Neuroscience Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant feature coded by the auditory cortex neurons projecting to primary visual cortex (V1). In V1, a small number of layer 1 interneurons gates this cross-modal information flow in a context-dependent manner. In dark conditions, auditory cortex inputs lead to suppression of the V1 population. However, when sound input coincides with a visual stimulus, visual responses are boosted in V1, most strongly after loud sound onsets. Thus, a dynamic, asymmetric circuit connecting AC and V1 contributes to the encoding of visual events that are coincident with sounds. eLife Sciences Publications, Ltd 2019-05-23 /pmc/articles/PMC6544434/ /pubmed/31115334 http://dx.doi.org/10.7554/eLife.44006 Text en © 2019, Deneux et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Deneux, Thomas
Harrell, Evan R
Kempf, Alexandre
Ceballo, Sebastian
Filipchuk, Anton
Bathellier, Brice
Context-dependent signaling of coincident auditory and visual events in primary visual cortex
title Context-dependent signaling of coincident auditory and visual events in primary visual cortex
title_full Context-dependent signaling of coincident auditory and visual events in primary visual cortex
title_fullStr Context-dependent signaling of coincident auditory and visual events in primary visual cortex
title_full_unstemmed Context-dependent signaling of coincident auditory and visual events in primary visual cortex
title_short Context-dependent signaling of coincident auditory and visual events in primary visual cortex
title_sort context-dependent signaling of coincident auditory and visual events in primary visual cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544434/
https://www.ncbi.nlm.nih.gov/pubmed/31115334
http://dx.doi.org/10.7554/eLife.44006
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