Cargando…
Context-dependent signaling of coincident auditory and visual events in primary visual cortex
Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant fe...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544434/ https://www.ncbi.nlm.nih.gov/pubmed/31115334 http://dx.doi.org/10.7554/eLife.44006 |
_version_ | 1783423257896026112 |
---|---|
author | Deneux, Thomas Harrell, Evan R Kempf, Alexandre Ceballo, Sebastian Filipchuk, Anton Bathellier, Brice |
author_facet | Deneux, Thomas Harrell, Evan R Kempf, Alexandre Ceballo, Sebastian Filipchuk, Anton Bathellier, Brice |
author_sort | Deneux, Thomas |
collection | PubMed |
description | Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant feature coded by the auditory cortex neurons projecting to primary visual cortex (V1). In V1, a small number of layer 1 interneurons gates this cross-modal information flow in a context-dependent manner. In dark conditions, auditory cortex inputs lead to suppression of the V1 population. However, when sound input coincides with a visual stimulus, visual responses are boosted in V1, most strongly after loud sound onsets. Thus, a dynamic, asymmetric circuit connecting AC and V1 contributes to the encoding of visual events that are coincident with sounds. |
format | Online Article Text |
id | pubmed-6544434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-65444342019-06-12 Context-dependent signaling of coincident auditory and visual events in primary visual cortex Deneux, Thomas Harrell, Evan R Kempf, Alexandre Ceballo, Sebastian Filipchuk, Anton Bathellier, Brice eLife Neuroscience Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant feature coded by the auditory cortex neurons projecting to primary visual cortex (V1). In V1, a small number of layer 1 interneurons gates this cross-modal information flow in a context-dependent manner. In dark conditions, auditory cortex inputs lead to suppression of the V1 population. However, when sound input coincides with a visual stimulus, visual responses are boosted in V1, most strongly after loud sound onsets. Thus, a dynamic, asymmetric circuit connecting AC and V1 contributes to the encoding of visual events that are coincident with sounds. eLife Sciences Publications, Ltd 2019-05-23 /pmc/articles/PMC6544434/ /pubmed/31115334 http://dx.doi.org/10.7554/eLife.44006 Text en © 2019, Deneux et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Deneux, Thomas Harrell, Evan R Kempf, Alexandre Ceballo, Sebastian Filipchuk, Anton Bathellier, Brice Context-dependent signaling of coincident auditory and visual events in primary visual cortex |
title | Context-dependent signaling of coincident auditory and visual events in primary visual cortex |
title_full | Context-dependent signaling of coincident auditory and visual events in primary visual cortex |
title_fullStr | Context-dependent signaling of coincident auditory and visual events in primary visual cortex |
title_full_unstemmed | Context-dependent signaling of coincident auditory and visual events in primary visual cortex |
title_short | Context-dependent signaling of coincident auditory and visual events in primary visual cortex |
title_sort | context-dependent signaling of coincident auditory and visual events in primary visual cortex |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544434/ https://www.ncbi.nlm.nih.gov/pubmed/31115334 http://dx.doi.org/10.7554/eLife.44006 |
work_keys_str_mv | AT deneuxthomas contextdependentsignalingofcoincidentauditoryandvisualeventsinprimaryvisualcortex AT harrellevanr contextdependentsignalingofcoincidentauditoryandvisualeventsinprimaryvisualcortex AT kempfalexandre contextdependentsignalingofcoincidentauditoryandvisualeventsinprimaryvisualcortex AT ceballosebastian contextdependentsignalingofcoincidentauditoryandvisualeventsinprimaryvisualcortex AT filipchukanton contextdependentsignalingofcoincidentauditoryandvisualeventsinprimaryvisualcortex AT bathellierbrice contextdependentsignalingofcoincidentauditoryandvisualeventsinprimaryvisualcortex |