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Frequency and signature of somatic variants in 1461 human brain exomes

PURPOSE: To systematically study somatic variants arising during development in the human brain across a spectrum of neurodegenerative disorders. METHODS: In this study we developed a pipeline to identify somatic variants from exome sequencing data in 1461 diseased and control human brains. Eighty-e...

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Detalles Bibliográficos
Autores principales:	Wei, Wei, Keogh, Michael J., Aryaman, Juvid, Golder, Zoe, Kullar, Peter J., Wilson, Ian, Talbot, Kevin, Turner, Martin R., McKenzie, Chris-Anne, Troakes, Claire, Attems, Johannes, Smith, Colin, Sarraj, Safa Al, Morris, Chris M., Ansorge, Olaf, Jones, Nick S., Ironside, James W., Chinnery, Patrick F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544539/ https://www.ncbi.nlm.nih.gov/pubmed/30214067 http://dx.doi.org/10.1038/s41436-018-0274-3

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