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Immunoproteasome activation enables human TRIM5α restriction of HIV-1

Type 1 interferon (IFN) suppresses viral replication by upregulating the expression of interferon-stimulated genes (ISGs) with diverse anti-viral properties1. The replication of human immunodeficiency virus type-1 (HIV-1) is naturally inhibited by IFN, with the steps between viral entry and chromoso...

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Detalles Bibliográficos
Autores principales:	Jimenez-Guardeño, Jose M., Apolonia, Luis, Betancor, Gilberto, Malim, Michael H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544544/ https://www.ncbi.nlm.nih.gov/pubmed/30886358 http://dx.doi.org/10.1038/s41564-019-0402-0

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