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Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells

BACKGROUND: Intra-tumor heterogeneity stems from genetic, epigenetic, functional, and environmental differences among tumor cells. A major source of genetic heterogeneity comes from DNA sequence differences and/or whole chromosome and focal copy number variations (CNVs). Whole chromosome CNVs are ca...

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Detalles Bibliográficos
Autores principales:	Zhao, Yanding, Carter, Robert, Natarajan, Sivaraman, Varn, Frederick S., Compton, Duane A., Gawad, Charles, Cheng, Chao, Godek, Kristina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545015/ https://www.ncbi.nlm.nih.gov/pubmed/31151460 http://dx.doi.org/10.1186/s12920-019-0532-5

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