K-ras-ERK1/2 down-regulates H2A.X(Y142ph) through WSTF to promote the progress of gastric cancer

BACKGROUND: Histone H2AX phosphorylation at the site of Tyr-142 can participates in multiple biological progressions, which is including DNA repair. Ras pathway is closely involved in human cancers. Our study investigated the effects of Ras pathway via regulating H2AX.(Y142ph). METHODS: Gastric canc...

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Detalles Bibliográficos
Autores principales: Dong, Chao, Sun, Jing, Ma, Sha, Zhang, Guoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545063/
https://www.ncbi.nlm.nih.gov/pubmed/31151422
http://dx.doi.org/10.1186/s12885-019-5750-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545063/
https://www.ncbi.nlm.nih.gov/pubmed/31151422
http://dx.doi.org/10.1186/s12885-019-5750-x

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