rSjp40 inhibits activated hepatic stellate cells by promoting nuclear translocation of YB1 and inducing BMP-7/Smad1/5/8 pathway

BACKGROUND: Activation of hepatic stellate cells is the dominant pathogenic event during the process of liver fibrosis. Bone morphogenic protein (BMP)-7 has recently been identified as an anti-fibrotic factor and leads to phosphorylation of Smad1/5/8 in activated hepatic stellate cells. Its expressi...

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Detalles Bibliográficos
Autores principales: Chen, Liuting, Zhou, Qi, Liu, Ertao, Zhang, Jiali, Duan, Lian, Zhu, Dandan, Chen, Jinling, Duan, Yinong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545069/
https://www.ncbi.nlm.nih.gov/pubmed/31151477
http://dx.doi.org/10.1186/s13071-019-3539-z

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