Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis

Growth hormone (GH) binds to its receptor (growth hormone receptor [GHR]) to exert its pleiotropic effects on growth and metabolism. Disrupted GH/GHR actions not only fail growth but also are involved in many metabolic disorders, as shown in murine models with global or tissue-specific Ghr deficienc...

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Detalles Bibliográficos
Autores principales: Ran, Liyuan, Wang, Xiaoshuang, Mi, Ai, Liu, Yanshuang, Wu, Jin, Wang, Haoan, Guo, Meihua, Sun, Jie, Liu, Bo, Li, Youwei, Wang, Dan, Jiang, Rujiao, Wang, Ning, Gao, Wenting, Zeng, Li, Huang, Lin, Chen, Xiaoli, LeRoith, Derek, Liang, Bin, Li, Xin, Wu, Yingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545351/
https://www.ncbi.nlm.nih.gov/pubmed/31154207
http://dx.doi.org/10.1016/j.isci.2019.05.020

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