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Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination

Measurement of malaria specific antibody responses represents a practical and informative method for malaria control programs to assess recent exposure to infection. Technical advances in recombinant antigen production, serological screening platforms, and analytical methods have enabled the identif...

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Autores principales: Greenhouse, Bryan, Daily, Jennifer, Guinovart, Caterina, Goncalves, Bronner, Beeson, James, Bell, David, Chang, Michelle A., Cohen, Justin M., Ding, Xavier, Domingo, Gonzalo, Eisele, Thomas P., Lammie, Patrick J., Mayor, Alfredo, Merienne, Nicolas, Monteiro, Wuelto, Painter, John, Rodriguez, Isabel, White, Michael, Drakeley, Chris, Mueller, Ivo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545519/
https://www.ncbi.nlm.nih.gov/pubmed/31172051
http://dx.doi.org/10.12688/gatesopenres.12897.1
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author Greenhouse, Bryan
Daily, Jennifer
Guinovart, Caterina
Goncalves, Bronner
Beeson, James
Bell, David
Chang, Michelle A.
Cohen, Justin M.
Ding, Xavier
Domingo, Gonzalo
Eisele, Thomas P.
Lammie, Patrick J.
Mayor, Alfredo
Merienne, Nicolas
Monteiro, Wuelto
Painter, John
Rodriguez, Isabel
White, Michael
Drakeley, Chris
Mueller, Ivo
author_facet Greenhouse, Bryan
Daily, Jennifer
Guinovart, Caterina
Goncalves, Bronner
Beeson, James
Bell, David
Chang, Michelle A.
Cohen, Justin M.
Ding, Xavier
Domingo, Gonzalo
Eisele, Thomas P.
Lammie, Patrick J.
Mayor, Alfredo
Merienne, Nicolas
Monteiro, Wuelto
Painter, John
Rodriguez, Isabel
White, Michael
Drakeley, Chris
Mueller, Ivo
author_sort Greenhouse, Bryan
collection PubMed
description Measurement of malaria specific antibody responses represents a practical and informative method for malaria control programs to assess recent exposure to infection. Technical advances in recombinant antigen production, serological screening platforms, and analytical methods have enabled the identification of several target antigens for laboratory based and point-of-contact tests. Questions remain as to how these serological assays can best be integrated into malaria surveillance activities to inform programmatic decision-making. This report synthesizes discussions from a convening at Institut Pasteur in Paris in June 2017 aimed at defining practical and informative use cases for serology applications and highlights five programmatic uses for serological assays including: documenting the absence of transmission; stratification of transmission; measuring the effect of interventions; informing a decentralized immediate response;  and testing and treating P. vivax hypnozoite carriers.
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spelling pubmed-65455192019-06-06 Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination Greenhouse, Bryan Daily, Jennifer Guinovart, Caterina Goncalves, Bronner Beeson, James Bell, David Chang, Michelle A. Cohen, Justin M. Ding, Xavier Domingo, Gonzalo Eisele, Thomas P. Lammie, Patrick J. Mayor, Alfredo Merienne, Nicolas Monteiro, Wuelto Painter, John Rodriguez, Isabel White, Michael Drakeley, Chris Mueller, Ivo Gates Open Res Open Letter Measurement of malaria specific antibody responses represents a practical and informative method for malaria control programs to assess recent exposure to infection. Technical advances in recombinant antigen production, serological screening platforms, and analytical methods have enabled the identification of several target antigens for laboratory based and point-of-contact tests. Questions remain as to how these serological assays can best be integrated into malaria surveillance activities to inform programmatic decision-making. This report synthesizes discussions from a convening at Institut Pasteur in Paris in June 2017 aimed at defining practical and informative use cases for serology applications and highlights five programmatic uses for serological assays including: documenting the absence of transmission; stratification of transmission; measuring the effect of interventions; informing a decentralized immediate response;  and testing and treating P. vivax hypnozoite carriers. F1000 Research Limited 2019-02-12 /pmc/articles/PMC6545519/ /pubmed/31172051 http://dx.doi.org/10.12688/gatesopenres.12897.1 Text en Copyright: © 2019 Greenhouse B et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Open Letter
Greenhouse, Bryan
Daily, Jennifer
Guinovart, Caterina
Goncalves, Bronner
Beeson, James
Bell, David
Chang, Michelle A.
Cohen, Justin M.
Ding, Xavier
Domingo, Gonzalo
Eisele, Thomas P.
Lammie, Patrick J.
Mayor, Alfredo
Merienne, Nicolas
Monteiro, Wuelto
Painter, John
Rodriguez, Isabel
White, Michael
Drakeley, Chris
Mueller, Ivo
Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination
title Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination
title_full Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination
title_fullStr Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination
title_full_unstemmed Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination
title_short Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination
title_sort priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination
topic Open Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545519/
https://www.ncbi.nlm.nih.gov/pubmed/31172051
http://dx.doi.org/10.12688/gatesopenres.12897.1
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