Interactions between oxytocin receptor gene and intergroup relationship on empathic neural responses to others’ pain

Empathic neural responses to others’ suffering are subject to both social and biological influences. The present study tested the hypothesis that empathic neural responses to others’ pain are more flexible in an intergroup context in G/G than A/A carriers of the oxytocin receptor gene (OXTR) (rs53576). We recorded event-related brain potentials to painful vs neutral expressions of Asian and Caucasian faces that were assigned to a fellow team or an opponent team in Chinese carriers of G/G or A/A allele of OXTR. We found that G/G carriers showed greater neural responses at 136–176 ms (P2) over the frontal/central region to painful vs neutral expressions of faces with shared either racial or mini group identity. In contrast, A/A carriers showed significant empathic neural responses in the P2 time window only to the faces with both shared racial and mini group identity. Moreover, the racial in-group bias in empathic neural responses varied across individuals’ empathy traits and ethnic identity for G/G but not A/A carriers. Our findings provide electrophysiological evidence for greater flexibility of empathic neural responses in intergroup contexts in G/G (vs A/A) carriers of OXTR and suggest interactions between OXTR and intergroup relationships on empathy for others’ suffering.