Linkage analysis and whole exome sequencing identify a novel candidate gene in a Dutch multiple sclerosis family

BACKGROUND: Multiple sclerosis (MS) is a complex disease resulting from the joint effect of many genes. It has been speculated that rare variants might explain part of the missing heritability of MS. OBJECTIVE: To identify rare coding genetic variants by analyzing a large MS pedigree with 11 affecte...

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Detalles Bibliográficos
Autores principales: Mescheriakova, Julia Y, Verkerk, Annemieke JMH, Amin, Najaf, Uitterlinden, André G, van Duijn, Cornelia M, Hintzen, Rogier Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545620/
https://www.ncbi.nlm.nih.gov/pubmed/29873607
http://dx.doi.org/10.1177/1352458518777202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545620/
https://www.ncbi.nlm.nih.gov/pubmed/29873607
http://dx.doi.org/10.1177/1352458518777202

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