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Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome

Chronic consumption of diets high in fat leads to obesity and can negatively affect brain function. Rodents made obese by long-term maintenance on a high-fat diet have worse outcome after experimental stroke. High-fat consumption for only three days does not induce obesity but has rapid effects on t...

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Autores principales: Haley, Michael J, Krishnan, Siddharth, Burrows, David, de Hoog, Leon, Thakrar, Jamie, Schiessl, Ingo, Allan, Stuart M, Lawrence, Catherine B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545621/
https://www.ncbi.nlm.nih.gov/pubmed/29171775
http://dx.doi.org/10.1177/0271678X17744718
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author Haley, Michael J
Krishnan, Siddharth
Burrows, David
de Hoog, Leon
Thakrar, Jamie
Schiessl, Ingo
Allan, Stuart M
Lawrence, Catherine B
author_facet Haley, Michael J
Krishnan, Siddharth
Burrows, David
de Hoog, Leon
Thakrar, Jamie
Schiessl, Ingo
Allan, Stuart M
Lawrence, Catherine B
author_sort Haley, Michael J
collection PubMed
description Chronic consumption of diets high in fat leads to obesity and can negatively affect brain function. Rodents made obese by long-term maintenance on a high-fat diet have worse outcome after experimental stroke. High-fat consumption for only three days does not induce obesity but has rapid effects on the brain including memory impairment. However, the effect of brief periods of high-fat feeding or high-fat consumption in the absence of obesity on stroke is unknown. We therefore tested the effect of an acute period of high-fat feeding (three days) in C57B/6 mice on outcome after middle cerebral artery occlusion (MCAo). In contrast to a chronic high-fat diet (7.5 months), an acute high-fat diet had no effect on body weight, adipose tissue, lipid profile or inflammatory markers (in periphery and the brain). Three days of high-fat feeding impaired glucose tolerance, increased plasma glucose and insulin and brain expression of the glucose transporter GLUT-1. Ischaemic damage was increased (48%) in mice fed an acute high-fat diet, and was associated with a further reduction in GLUT-1 in the ischaemic hemisphere. These data demonstrate that only a brief period of high-fat consumption has a negative effect on glucose homeostasis and worsens outcome after ischaemic stroke.
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spelling pubmed-65456212019-06-25 Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome Haley, Michael J Krishnan, Siddharth Burrows, David de Hoog, Leon Thakrar, Jamie Schiessl, Ingo Allan, Stuart M Lawrence, Catherine B J Cereb Blood Flow Metab Original Articles Chronic consumption of diets high in fat leads to obesity and can negatively affect brain function. Rodents made obese by long-term maintenance on a high-fat diet have worse outcome after experimental stroke. High-fat consumption for only three days does not induce obesity but has rapid effects on the brain including memory impairment. However, the effect of brief periods of high-fat feeding or high-fat consumption in the absence of obesity on stroke is unknown. We therefore tested the effect of an acute period of high-fat feeding (three days) in C57B/6 mice on outcome after middle cerebral artery occlusion (MCAo). In contrast to a chronic high-fat diet (7.5 months), an acute high-fat diet had no effect on body weight, adipose tissue, lipid profile or inflammatory markers (in periphery and the brain). Three days of high-fat feeding impaired glucose tolerance, increased plasma glucose and insulin and brain expression of the glucose transporter GLUT-1. Ischaemic damage was increased (48%) in mice fed an acute high-fat diet, and was associated with a further reduction in GLUT-1 in the ischaemic hemisphere. These data demonstrate that only a brief period of high-fat consumption has a negative effect on glucose homeostasis and worsens outcome after ischaemic stroke. SAGE Publications 2017-11-24 2019-06 /pmc/articles/PMC6545621/ /pubmed/29171775 http://dx.doi.org/10.1177/0271678X17744718 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Haley, Michael J
Krishnan, Siddharth
Burrows, David
de Hoog, Leon
Thakrar, Jamie
Schiessl, Ingo
Allan, Stuart M
Lawrence, Catherine B
Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome
title Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome
title_full Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome
title_fullStr Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome
title_full_unstemmed Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome
title_short Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome
title_sort acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545621/
https://www.ncbi.nlm.nih.gov/pubmed/29171775
http://dx.doi.org/10.1177/0271678X17744718
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