Cargando…

Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients

BACKGROUND: Clinical data identified an association between the use of HMG-CoA reductase inhibitors (statins) and incident diabetes in patients with underlying diabetes risk factors such as obesity, hypertension and dyslipidemia. The molecular mechanisms however are unknown. METHODS: An observationa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Margerie, Daniel, Lefebvre, Philippe, Raverdy, Violeta, Schwahn, Uwe, Ruetten, Hartmut, Larsen, Philip, Duhamel, Alain, Labreuche, Julien, Thuillier, Dorothée, Derudas, Bruno, Gheeraert, Céline, Dehondt, Hélène, Dhalluin, Quentin, Alexandre, Jérémy, Caiazzo, Robert, Nesslany, Pamela, Verkindt, Helene, Pattou, François, Staels, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545676/ https://www.ncbi.nlm.nih.gov/pubmed/31159817 http://dx.doi.org/10.1186/s12920-019-0536-1

Ejemplares similares

Hepatic Molecular Signatures Highlight the Sexual Dimorphism of Nonalcoholic Steatohepatitis (NASH)
por: Vandel, Jimmy, et al.
Publicado: (2020)

The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ
por: Firmin, François F., et al.
Publicado: (2017)

NASH-related increases in plasma bile acid levels depend on insulin resistance
por: Grzych, Guillaume, et al.
Publicado: (2020)

A dynamic CTCF chromatin binding landscape promotes DNA hydroxymethylation and transcriptional induction of adipocyte differentiation
por: Dubois-Chevalier, Julie, et al.
Publicado: (2014)

Letter to the editor: Regression of liver fibrosis after bariatric operations: A glass two‐third full rather than half empty
por: Pattou, François, et al.
Publicado: (2022)

Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis
por: Favennec, Marie, et al.
Publicado: (2016)

Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis
por: Ding, Lianggong, et al.
Publicado: (2021)

The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions
por: Dubois-Chevalier, Julie, et al.
Publicado: (2017)

An Evaluation of the Implementation of the European Calcified Tissue Society Recommendations on the Prevention and Treatment of Osteoporosis Secondary to Bariatric Surgery
por: Courtalin, Marion, et al.
Publicado: (2023)

Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis
por: Dehondt, Hélène, et al.
Publicado: (2023)

GIANT: galaxy-based tool for interactive analysis of transcriptomic data
por: Vandel, Jimmy, et al.
Publicado: (2020)

Farnesoid X Receptor Inhibits Glucagon-Like Peptide-1 Production by Enteroendocrine L-cells
por: TRABELSI, Mohamed-Sami, et al.
Publicado: (2015)

Determinants of the Cost-Effectiveness of Statins
por: Morrison, Alan, et al.
Publicado: (2003)

Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis
por: Bobowski-Gerard, Marie, et al.
Publicado: (2022)

Comparison of In Vitro Endocrine Activity of Phthalates and Alternative Plasticizers
por: Moche, Hélène, et al.
Publicado: (2021)

Erratum. Ten-Year Outcome of Islet Alone or Islet After Kidney Transplantation in Type 1 Diabetes: A Prospective Parallel-Arm Cohort Study. Diabetes Care 2019;42:2042–2049
por: Vantyghem, Marie-Christine, et al.
Publicado: (2020)

Meta‐analysis of genome‐wide DNA methylation and integrative omics of age in human skeletal muscle
por: Voisin, Sarah, et al.
Publicado: (2021)

Peroxisome Proliferator-Activated Receptor γ Induces the Expression of Tissue Factor Pathway Inhibitor-1 (TFPI-1) in Human Macrophages
por: Chinetti-Gbaguidi, G., et al.
Publicado: (2016)

Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver
por: Dubois, Vanessa, et al.
Publicado: (2020)

Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice
por: Brachs, Sebastian, et al.
Publicado: (2016)

Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach
por: Bonnefond, Amélie, et al.
Publicado: (2017)

Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult Mice
por: Brachs, Sebastian, et al.
Publicado: (2016)

Correction: Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult Mice
por: Brachs, Sebastian, et al.
Publicado: (2017)

Primary Graft Function, Metabolic Control, and Graft Survival After Islet Transplantation
por: Vantyghem, Marie-Christine, et al.
Publicado: (2009)

The tumour suppressor CDKN2A/p16(INK4a) regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissue
por: Wouters, Kristiaan, et al.
Publicado: (2017)

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism
por: Deprince, Audrey, et al.
Publicado: (2023)

Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex
por: Berthier, Alexandre, et al.
Publicado: (2018)

Fingolimod treatment modulates PPARγ and CD36 gene expression in women with multiple sclerosis
por: Ferret-Sena, Véronique, et al.
Publicado: (2022)

Adaptive changes of human islets to an obesogenic environment in the mouse
por: Gargani, S., et al.
Publicado: (2012)

Joint latent class model: Simulation study of model properties and application to amyotrophic lateral sclerosis disease
por: Kyheng, Maéva, et al.
Publicado: (2021)

An extended transcription factor regulatory network controls hepatocyte identity
por: Dubois‐Chevalier, Julie, et al.
Publicado: (2023)

Impaired Expression of the Inducible cAMP Early Repressor Accounts for Sustained Adipose CREB Activity in Obesity
por: Favre, Dimitri, et al.
Publicado: (2011)

Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function
por: Bricambert, Julien, et al.
Publicado: (2016)

Should statin guidelines consider patient preferences? Eliciting preferences of benefit and harm outcomes of statins for primary prevention of cardiovascular disease in the sub-Saharan African and European contexts
por: Yebyo, Henock G., et al.
Publicado: (2018)

Efficacy and Safety in Retinal Vein Occlusion Treated with at Least Three Consecutive Intravitreal Dexamethasone Implants
por: Proença Pina, Julia, et al.
Publicado: (2016)

Natalizumab Treatment Modulates Peroxisome Proliferator-Activated Receptors Expression in Women with Multiple Sclerosis
por: Ferret-Sena, Véronique, et al.
Publicado: (2016)

From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials
por: Fessard, Valérie, et al.
Publicado: (2020)

An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells
por: Berthier, Alexandre, et al.
Publicado: (2021)

A Rapidly Progressive Case of Statin-induced Necrotizing Autoimmune Myopathy
por: Ahmed, Sundus, et al.
Publicado: (2020)

Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes
por: Zubiaga, Lorea, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vnf72ml8s9d8o0fpujouvforlm