A dual controllability analysis of influenza virus-host protein-protein interaction networks for antiviral drug target discovery

BACKGROUND: Host factors of influenza virus replication are often found in key topological positions within protein-protein interaction networks. This work explores how protein states can be manipulated through controllability analysis: the determination of the minimum manipulation needed to drive t...

Descripción completa

Detalles Bibliográficos
Autores principales: Ackerman, Emily E., Alcorn, John F., Hase, Takeshi, Shoemaker, Jason E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545738/
https://www.ncbi.nlm.nih.gov/pubmed/31159726
http://dx.doi.org/10.1186/s12859-019-2917-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545738/
https://www.ncbi.nlm.nih.gov/pubmed/31159726
http://dx.doi.org/10.1186/s12859-019-2917-z

Ejemplares similares