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Diagnostic Accuracy of the Xpert MTB/RIF Assay for Lymph Node Tuberculosis: A Systematic Review and Meta-Analysis

OBJECTIVES: To evaluate the performance of Xpert MTB/RIF for lymph node tuberculosis (LNTB). METHODS: We searched databases for published reports. We reviewed the studies and identified the performance of Xpert MTB/RIF with respect to a composite reference standard (CRS) and culture. We used a bivar...

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Detalles Bibliográficos
Autores principales: Yu, Guocan, Zhong, Fangming, Ye, Bo, Xu, Xudong, Chen, Da, Shen, Yanqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545759/
https://www.ncbi.nlm.nih.gov/pubmed/31236407
http://dx.doi.org/10.1155/2019/4878240
Descripción
Sumario:OBJECTIVES: To evaluate the performance of Xpert MTB/RIF for lymph node tuberculosis (LNTB). METHODS: We searched databases for published reports. We reviewed the studies and identified the performance of Xpert MTB/RIF with respect to a composite reference standard (CRS) and culture. We used a bivariate random-effects model to perform meta-analyses and used metaregression to analyze sources of heterogeneity. RESULTS: 15 independent studies compared Xpert MTB/RIF with CRS while 21 comparing it with culture were included. The pooled sensitivity and specificity of Xpert MTB/RIF were 79% and 98% compared to that of CRS, respectively, and 84% and 91% compared to that of culture, respectively. The pooled sensitivity and specificity using fine needle aspiration (FNA) samples versus CRS were 80% and 96%, whereas those against culture were 90% and 89%, respectively. The percentages while working with tissue samples versus CRS were 76% and 100%, respectively, whereas those against culture were 76% and 92%, respectively. There was no significant difference in diagnostic efficiency among the types of specimen. CONCLUSIONS: Xpert MTB/RIF demonstrates good diagnostic efficiency for LNTB and is not related to the type of specimen, obtained via different routes.