The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled

The U.S. Drug Induced Liver Injury Network assayed the contents of herbal and dietary supplements collected from patients enrolled into its prospective study. The aim was to determine the accuracy of product labels, and to identify known hepatotoxins. Using high‐performance liquid chromatography cou...

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Autores principales: Navarro, Victor, Avula, Bharathi, Khan, Ikhlas, Verma, Manisha, Seeff, Leonard, Serrano, Jose, Stolz, Andrew, Fontana, Robert, Ahmad, Jawad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545864/
https://www.ncbi.nlm.nih.gov/pubmed/31168513
http://dx.doi.org/10.1002/hep4.1346
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author Navarro, Victor
Avula, Bharathi
Khan, Ikhlas
Verma, Manisha
Seeff, Leonard
Serrano, Jose
Stolz, Andrew
Fontana, Robert
Ahmad, Jawad
author_facet Navarro, Victor
Avula, Bharathi
Khan, Ikhlas
Verma, Manisha
Seeff, Leonard
Serrano, Jose
Stolz, Andrew
Fontana, Robert
Ahmad, Jawad
author_sort Navarro, Victor
collection PubMed
description The U.S. Drug Induced Liver Injury Network assayed the contents of herbal and dietary supplements collected from patients enrolled into its prospective study. The aim was to determine the accuracy of product labels, and to identify known hepatotoxins. Using high‐performance liquid chromatography coupled with mass spectrometry to assay 272 product, 51% were found to be mislabeled; that is, to have chemical contents that did not match the label. Appearance enhancement, sexual performance, and weight loss products were most commonly mislabeled. Whether the mislabeling contributed to liver injury is under study; however, the high mislabeling rate underscores the need for more stringent regulation of supplements.
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spelling pubmed-65458642019-06-05 The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled Navarro, Victor Avula, Bharathi Khan, Ikhlas Verma, Manisha Seeff, Leonard Serrano, Jose Stolz, Andrew Fontana, Robert Ahmad, Jawad Hepatol Commun Original Articles The U.S. Drug Induced Liver Injury Network assayed the contents of herbal and dietary supplements collected from patients enrolled into its prospective study. The aim was to determine the accuracy of product labels, and to identify known hepatotoxins. Using high‐performance liquid chromatography coupled with mass spectrometry to assay 272 product, 51% were found to be mislabeled; that is, to have chemical contents that did not match the label. Appearance enhancement, sexual performance, and weight loss products were most commonly mislabeled. Whether the mislabeling contributed to liver injury is under study; however, the high mislabeling rate underscores the need for more stringent regulation of supplements. John Wiley and Sons Inc. 2019-04-03 /pmc/articles/PMC6545864/ /pubmed/31168513 http://dx.doi.org/10.1002/hep4.1346 Text en © 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Navarro, Victor
Avula, Bharathi
Khan, Ikhlas
Verma, Manisha
Seeff, Leonard
Serrano, Jose
Stolz, Andrew
Fontana, Robert
Ahmad, Jawad
The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled
title The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled
title_full The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled
title_fullStr The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled
title_full_unstemmed The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled
title_short The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled
title_sort contents of herbal and dietary supplements implicated in liver injury in the united states are frequently mislabeled
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545864/
https://www.ncbi.nlm.nih.gov/pubmed/31168513
http://dx.doi.org/10.1002/hep4.1346
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