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Efficacy of Intra-articular Dexmedetomidine versus Buprenorphine for Postoperative Analgesia following Knee Arthroscopy: A Comparative Study

BACKGROUND: Arthroscopic knee surgery is most commonly performed minimally invasive surgical procedure in orthopaedics. Postoperative pain relief is must for early mobilisation that reduces patient's morbidity and improves postoperative recovery. AIMS AND OBJECTIVES: We sought to compare analge...

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Autores principales: Das, Pulin Bihari, Samal, Soumya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545935/
https://www.ncbi.nlm.nih.gov/pubmed/31198235
http://dx.doi.org/10.4103/aer.AER_33_19
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author Das, Pulin Bihari
Samal, Soumya
author_facet Das, Pulin Bihari
Samal, Soumya
author_sort Das, Pulin Bihari
collection PubMed
description BACKGROUND: Arthroscopic knee surgery is most commonly performed minimally invasive surgical procedure in orthopaedics. Postoperative pain relief is must for early mobilisation that reduces patient's morbidity and improves postoperative recovery. AIMS AND OBJECTIVES: We sought to compare analgesic efficacy of intraarticular buprenorphine with dexmedetomidine following arthroscopic surgery of knee. SETTINGS AND DESIGN: A prospective , randomized controlled double blinded study was conducted involving 60 patients undergoing arthroscopic knee surgery. MATERIALS AND METHODS: Patients were allocated into group B (n = 30) and group D (n = 30) receiving 100 μg of intraarticular buprenorphine and 100 μg of intraarticular dexmedetomidine respectively. Parameters observed were the time to first rescue analgesia , the number of patients requiring rescue analgesia with in next 24 hours, Visual analogue scale (VAS) at rest and on mobilization at 1(st), 2(nd), 4(th), 8(th), 12(th) and 24(th) hour. STATISTICAL ANALYSIS: Quantitative data were analyzed by unpaired student's t test and categorical data by Fisher's exact test. A P < 0.05 was considered to be significant. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS 19.0, SPSS Inc., Chicago, IL, USA). RESULTS: Time to first rescue analgesia was significantly longer in patients receiving in group B. VAS scores at rest were comparable between the groups at 1(st), 2(nd), 4(th) and 8(th) hour but significantly low with intraarticular buprenorphine than intraarticular dexmedetomidine at 12(th) and 24(th) hour. VAS scores on ambulation were comparable at 1(st), 2(nd) and 4(th) hour but significantly higher in dexmedetomidine group as compared to buprenorphine at 8(th), 12(th) and 24(th) hour. CONCLUSION: Intraarticular buprenorphine 100 μg provides longer duration of analgesia with decreased postoperative rescue analgesic requirement as compared to 100 μg intraarticular dexmedetomidine.
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spelling pubmed-65459352019-06-13 Efficacy of Intra-articular Dexmedetomidine versus Buprenorphine for Postoperative Analgesia following Knee Arthroscopy: A Comparative Study Das, Pulin Bihari Samal, Soumya Anesth Essays Res Original Article BACKGROUND: Arthroscopic knee surgery is most commonly performed minimally invasive surgical procedure in orthopaedics. Postoperative pain relief is must for early mobilisation that reduces patient's morbidity and improves postoperative recovery. AIMS AND OBJECTIVES: We sought to compare analgesic efficacy of intraarticular buprenorphine with dexmedetomidine following arthroscopic surgery of knee. SETTINGS AND DESIGN: A prospective , randomized controlled double blinded study was conducted involving 60 patients undergoing arthroscopic knee surgery. MATERIALS AND METHODS: Patients were allocated into group B (n = 30) and group D (n = 30) receiving 100 μg of intraarticular buprenorphine and 100 μg of intraarticular dexmedetomidine respectively. Parameters observed were the time to first rescue analgesia , the number of patients requiring rescue analgesia with in next 24 hours, Visual analogue scale (VAS) at rest and on mobilization at 1(st), 2(nd), 4(th), 8(th), 12(th) and 24(th) hour. STATISTICAL ANALYSIS: Quantitative data were analyzed by unpaired student's t test and categorical data by Fisher's exact test. A P < 0.05 was considered to be significant. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS 19.0, SPSS Inc., Chicago, IL, USA). RESULTS: Time to first rescue analgesia was significantly longer in patients receiving in group B. VAS scores at rest were comparable between the groups at 1(st), 2(nd), 4(th) and 8(th) hour but significantly low with intraarticular buprenorphine than intraarticular dexmedetomidine at 12(th) and 24(th) hour. VAS scores on ambulation were comparable at 1(st), 2(nd) and 4(th) hour but significantly higher in dexmedetomidine group as compared to buprenorphine at 8(th), 12(th) and 24(th) hour. CONCLUSION: Intraarticular buprenorphine 100 μg provides longer duration of analgesia with decreased postoperative rescue analgesic requirement as compared to 100 μg intraarticular dexmedetomidine. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6545935/ /pubmed/31198235 http://dx.doi.org/10.4103/aer.AER_33_19 Text en Copyright: © 2019 Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Das, Pulin Bihari
Samal, Soumya
Efficacy of Intra-articular Dexmedetomidine versus Buprenorphine for Postoperative Analgesia following Knee Arthroscopy: A Comparative Study
title Efficacy of Intra-articular Dexmedetomidine versus Buprenorphine for Postoperative Analgesia following Knee Arthroscopy: A Comparative Study
title_full Efficacy of Intra-articular Dexmedetomidine versus Buprenorphine for Postoperative Analgesia following Knee Arthroscopy: A Comparative Study
title_fullStr Efficacy of Intra-articular Dexmedetomidine versus Buprenorphine for Postoperative Analgesia following Knee Arthroscopy: A Comparative Study
title_full_unstemmed Efficacy of Intra-articular Dexmedetomidine versus Buprenorphine for Postoperative Analgesia following Knee Arthroscopy: A Comparative Study
title_short Efficacy of Intra-articular Dexmedetomidine versus Buprenorphine for Postoperative Analgesia following Knee Arthroscopy: A Comparative Study
title_sort efficacy of intra-articular dexmedetomidine versus buprenorphine for postoperative analgesia following knee arthroscopy: a comparative study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545935/
https://www.ncbi.nlm.nih.gov/pubmed/31198235
http://dx.doi.org/10.4103/aer.AER_33_19
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