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A Comparative Clinical Study between Clonidine and Tramadol with Bupivacaine in Caudal Epidural for Postoperative Analgesia in Pediatric Surgery

CONTEXT: Adjuvants to bupivacaine for single shot caudal block in children. AIMS: This study entitled was conducted to compare the effects of addition of tramadol to bupivacaine over addition of clonidine to bupivacaine as a single shot caudal block in children. SETTINGS AND DESIGN: Sixty children o...

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Autores principales: Amitha, S, Metri, Vidyadhar, Mahadevaiah, Thejeswini, Yoganarasimha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545941/
https://www.ncbi.nlm.nih.gov/pubmed/31198265
http://dx.doi.org/10.4103/aer.AER_37_19
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author Amitha, S
Metri, Vidyadhar
Mahadevaiah, Thejeswini
Yoganarasimha,
author_facet Amitha, S
Metri, Vidyadhar
Mahadevaiah, Thejeswini
Yoganarasimha,
author_sort Amitha, S
collection PubMed
description CONTEXT: Adjuvants to bupivacaine for single shot caudal block in children. AIMS: This study entitled was conducted to compare the effects of addition of tramadol to bupivacaine over addition of clonidine to bupivacaine as a single shot caudal block in children. SETTINGS AND DESIGN: Sixty children of ASA grade I and II in the age group of 2-12 years coming for various infra-umbilical surgeries were included. MATERIALS AND METHODS: They were divided into two groups of 30 each. Group BC received caudal bupivacaine 0.25% 0.5ml/kg with clonidine 2 mcg/kg Group BT received caudal bupivacaine 0.25% 0.5 ml/kg with tramadol 2 mg/kg. The main parameters studied were hemodynamic changes, duration of post-operative analgesia and incidence of adverse effects. STATISTICAL ANALYSIS USED: The results of continuous variables are given as mean ± SD and proportion as percentage. The difference between the two groups was assessed by student's – t test and chi-square test RESULTS: The mean duration of post-operative analgesia in group BT was statistically significant (P <0.001), reducing the requirement of analgesics in group BT. There was no difference in sedation score, nausea, vomiting, urinary retention. CONCLUSIONS: The present study demonstrated that caudal administration of bupivacaine 0.25% 0.5 ml/kg with tramadol 2 mg/kg resulted in superior analgesia with longer duration of action and reduced requirement of analgesics in first 24 hours postoperatively when compared with 0.25% bupivacaine 0.5 ml/kg with clonidine 2 mcg/kg.
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spelling pubmed-65459412019-06-13 A Comparative Clinical Study between Clonidine and Tramadol with Bupivacaine in Caudal Epidural for Postoperative Analgesia in Pediatric Surgery Amitha, S Metri, Vidyadhar Mahadevaiah, Thejeswini Yoganarasimha, Anesth Essays Res Original Article CONTEXT: Adjuvants to bupivacaine for single shot caudal block in children. AIMS: This study entitled was conducted to compare the effects of addition of tramadol to bupivacaine over addition of clonidine to bupivacaine as a single shot caudal block in children. SETTINGS AND DESIGN: Sixty children of ASA grade I and II in the age group of 2-12 years coming for various infra-umbilical surgeries were included. MATERIALS AND METHODS: They were divided into two groups of 30 each. Group BC received caudal bupivacaine 0.25% 0.5ml/kg with clonidine 2 mcg/kg Group BT received caudal bupivacaine 0.25% 0.5 ml/kg with tramadol 2 mg/kg. The main parameters studied were hemodynamic changes, duration of post-operative analgesia and incidence of adverse effects. STATISTICAL ANALYSIS USED: The results of continuous variables are given as mean ± SD and proportion as percentage. The difference between the two groups was assessed by student's – t test and chi-square test RESULTS: The mean duration of post-operative analgesia in group BT was statistically significant (P <0.001), reducing the requirement of analgesics in group BT. There was no difference in sedation score, nausea, vomiting, urinary retention. CONCLUSIONS: The present study demonstrated that caudal administration of bupivacaine 0.25% 0.5 ml/kg with tramadol 2 mg/kg resulted in superior analgesia with longer duration of action and reduced requirement of analgesics in first 24 hours postoperatively when compared with 0.25% bupivacaine 0.5 ml/kg with clonidine 2 mcg/kg. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6545941/ /pubmed/31198265 http://dx.doi.org/10.4103/aer.AER_37_19 Text en Copyright: © 2019 Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Amitha, S
Metri, Vidyadhar
Mahadevaiah, Thejeswini
Yoganarasimha,
A Comparative Clinical Study between Clonidine and Tramadol with Bupivacaine in Caudal Epidural for Postoperative Analgesia in Pediatric Surgery
title A Comparative Clinical Study between Clonidine and Tramadol with Bupivacaine in Caudal Epidural for Postoperative Analgesia in Pediatric Surgery
title_full A Comparative Clinical Study between Clonidine and Tramadol with Bupivacaine in Caudal Epidural for Postoperative Analgesia in Pediatric Surgery
title_fullStr A Comparative Clinical Study between Clonidine and Tramadol with Bupivacaine in Caudal Epidural for Postoperative Analgesia in Pediatric Surgery
title_full_unstemmed A Comparative Clinical Study between Clonidine and Tramadol with Bupivacaine in Caudal Epidural for Postoperative Analgesia in Pediatric Surgery
title_short A Comparative Clinical Study between Clonidine and Tramadol with Bupivacaine in Caudal Epidural for Postoperative Analgesia in Pediatric Surgery
title_sort comparative clinical study between clonidine and tramadol with bupivacaine in caudal epidural for postoperative analgesia in pediatric surgery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545941/
https://www.ncbi.nlm.nih.gov/pubmed/31198265
http://dx.doi.org/10.4103/aer.AER_37_19
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