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Diet, the Gut Microbiome and Heart Failure
The collection of microorganisms that live in coexistence within or on the host body has been referred to as the microbiota. In humans, such cohabitation is mostly seen in the gut, mainly in the colon. The gut microbiome is acquired from the environment and is modified mostly by the diet. There are...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Radcliffe Cardiology
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545994/ https://www.ncbi.nlm.nih.gov/pubmed/31179023 http://dx.doi.org/10.15420/cfr.2018.39.2 |
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author | Harikrishnan, Sivadasanpillai |
author_facet | Harikrishnan, Sivadasanpillai |
author_sort | Harikrishnan, Sivadasanpillai |
collection | PubMed |
description | The collection of microorganisms that live in coexistence within or on the host body has been referred to as the microbiota. In humans, such cohabitation is mostly seen in the gut, mainly in the colon. The gut microbiome is acquired from the environment and is modified mostly by the diet. There are preliminary data to show that gut microbia can directly influence the pathogenetic disease processes in heart failure (HF). HF leads to bowel wall oedema and regional hypoxia, causing a change in the microbial flora of the gut, which can initiate or perpetuate certain pathogenetic process in HF. The structural component of the microbiota itself, such as lipopolysaccharides or the substances produced by the bacteria, such as trimethylamine N-oxide, is implicated in the pathogenesis of HF. This process is termed as the ‘heart–gut axis’ in HF. Manipulating the gut microbia or targeting products from the microbia may become treatment options for HF in future. |
format | Online Article Text |
id | pubmed-6545994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Radcliffe Cardiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-65459942019-06-07 Diet, the Gut Microbiome and Heart Failure Harikrishnan, Sivadasanpillai Card Fail Rev Co-Morbidities The collection of microorganisms that live in coexistence within or on the host body has been referred to as the microbiota. In humans, such cohabitation is mostly seen in the gut, mainly in the colon. The gut microbiome is acquired from the environment and is modified mostly by the diet. There are preliminary data to show that gut microbia can directly influence the pathogenetic disease processes in heart failure (HF). HF leads to bowel wall oedema and regional hypoxia, causing a change in the microbial flora of the gut, which can initiate or perpetuate certain pathogenetic process in HF. The structural component of the microbiota itself, such as lipopolysaccharides or the substances produced by the bacteria, such as trimethylamine N-oxide, is implicated in the pathogenesis of HF. This process is termed as the ‘heart–gut axis’ in HF. Manipulating the gut microbia or targeting products from the microbia may become treatment options for HF in future. Radcliffe Cardiology 2019-05-24 /pmc/articles/PMC6545994/ /pubmed/31179023 http://dx.doi.org/10.15420/cfr.2018.39.2 Text en Copyright © 2019, Radcliffe Cardiology https://creativecommons.org/licenses/by-nc/4.0/legalcode This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly. |
spellingShingle | Co-Morbidities Harikrishnan, Sivadasanpillai Diet, the Gut Microbiome and Heart Failure |
title | Diet, the Gut Microbiome and Heart Failure |
title_full | Diet, the Gut Microbiome and Heart Failure |
title_fullStr | Diet, the Gut Microbiome and Heart Failure |
title_full_unstemmed | Diet, the Gut Microbiome and Heart Failure |
title_short | Diet, the Gut Microbiome and Heart Failure |
title_sort | diet, the gut microbiome and heart failure |
topic | Co-Morbidities |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545994/ https://www.ncbi.nlm.nih.gov/pubmed/31179023 http://dx.doi.org/10.15420/cfr.2018.39.2 |
work_keys_str_mv | AT harikrishnansivadasanpillai dietthegutmicrobiomeandheartfailure |