A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B

Chronic infection by the hepatitis B virus (HBV) has remained a major public health problem. To achieve an HBV cure, we will likely need to combine antivirals with different viral targets as well as immunotherapy. Here, we report data from a pilot proof‐of‐concept clinical trial of nitazoxanide in t...

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Detalles Bibliográficos
Autores principales: Rossignol, Jean‐François, Bréchot, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546020/
https://www.ncbi.nlm.nih.gov/pubmed/31168509
http://dx.doi.org/10.1002/hep4.1339
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author Rossignol, Jean‐François
Bréchot, Christian
author_facet Rossignol, Jean‐François
Bréchot, Christian
author_sort Rossignol, Jean‐François
collection PubMed
description Chronic infection by the hepatitis B virus (HBV) has remained a major public health problem. To achieve an HBV cure, we will likely need to combine antivirals with different viral targets as well as immunotherapy. Here, we report data from a pilot proof‐of‐concept clinical trial of nitazoxanide in treating chronic hepatitis B. Conclusion: Nitazoxanide offers novel mechanisms of antiviral activity, and it would be interesting to evaluate the potential of combining nitazoxanide with oral nucleos(t)ide analogues.
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spelling pubmed-65460202019-06-05 A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B Rossignol, Jean‐François Bréchot, Christian Hepatol Commun Brief Report Chronic infection by the hepatitis B virus (HBV) has remained a major public health problem. To achieve an HBV cure, we will likely need to combine antivirals with different viral targets as well as immunotherapy. Here, we report data from a pilot proof‐of‐concept clinical trial of nitazoxanide in treating chronic hepatitis B. Conclusion: Nitazoxanide offers novel mechanisms of antiviral activity, and it would be interesting to evaluate the potential of combining nitazoxanide with oral nucleos(t)ide analogues. John Wiley and Sons Inc. 2019-03-29 /pmc/articles/PMC6546020/ /pubmed/31168509 http://dx.doi.org/10.1002/hep4.1339 Text en © 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Report
Rossignol, Jean‐François
Bréchot, Christian
A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B
title A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B
title_full A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B
title_fullStr A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B
title_full_unstemmed A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B
title_short A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B
title_sort pilot clinical trial of nitazoxanide in the treatment of chronic hepatitis b
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546020/
https://www.ncbi.nlm.nih.gov/pubmed/31168509
http://dx.doi.org/10.1002/hep4.1339
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