Editing the Central Nervous System Through CRISPR/Cas9 Systems

The translational gap to treatments based on gene therapy has been reduced in recent years because of improvements in gene editing tools, such as the CRISPR/Cas9 system and its variations. This has allowed the development of more precise therapies for neurodegenerative diseases, where access is priv...

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Detalles Bibliográficos
Autores principales: Cota-Coronado, Agustin, Díaz-Martínez, Néstor Fabián, Padilla-Camberos, Eduardo, Díaz-Martínez, N. Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546027/
https://www.ncbi.nlm.nih.gov/pubmed/31191241
http://dx.doi.org/10.3389/fnmol.2019.00110
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author Cota-Coronado, Agustin
Díaz-Martínez, Néstor Fabián
Padilla-Camberos, Eduardo
Díaz-Martínez, N. Emmanuel
author_facet Cota-Coronado, Agustin
Díaz-Martínez, Néstor Fabián
Padilla-Camberos, Eduardo
Díaz-Martínez, N. Emmanuel
author_sort Cota-Coronado, Agustin
collection PubMed
description The translational gap to treatments based on gene therapy has been reduced in recent years because of improvements in gene editing tools, such as the CRISPR/Cas9 system and its variations. This has allowed the development of more precise therapies for neurodegenerative diseases, where access is privileged. As a result, engineering of complexes that can access the central nervous system (CNS) with the least potential inconvenience is fundamental. In this review article, we describe current alternatives to generate systems based on CRISPR/Cas9 that can cross the blood–brain barrier (BBB) and may be used further clinically to improve treatment for neurodegeneration in Parkinson’s and Alzheimer’s disease (AD).
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spelling pubmed-65460272019-06-12 Editing the Central Nervous System Through CRISPR/Cas9 Systems Cota-Coronado, Agustin Díaz-Martínez, Néstor Fabián Padilla-Camberos, Eduardo Díaz-Martínez, N. Emmanuel Front Mol Neurosci Neuroscience The translational gap to treatments based on gene therapy has been reduced in recent years because of improvements in gene editing tools, such as the CRISPR/Cas9 system and its variations. This has allowed the development of more precise therapies for neurodegenerative diseases, where access is privileged. As a result, engineering of complexes that can access the central nervous system (CNS) with the least potential inconvenience is fundamental. In this review article, we describe current alternatives to generate systems based on CRISPR/Cas9 that can cross the blood–brain barrier (BBB) and may be used further clinically to improve treatment for neurodegeneration in Parkinson’s and Alzheimer’s disease (AD). Frontiers Media S.A. 2019-05-27 /pmc/articles/PMC6546027/ /pubmed/31191241 http://dx.doi.org/10.3389/fnmol.2019.00110 Text en Copyright © 2019 Cota-Coronado, Díaz-Martínez, Padilla-Camberos and Díaz-Martínez. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Cota-Coronado, Agustin
Díaz-Martínez, Néstor Fabián
Padilla-Camberos, Eduardo
Díaz-Martínez, N. Emmanuel
Editing the Central Nervous System Through CRISPR/Cas9 Systems
title Editing the Central Nervous System Through CRISPR/Cas9 Systems
title_full Editing the Central Nervous System Through CRISPR/Cas9 Systems
title_fullStr Editing the Central Nervous System Through CRISPR/Cas9 Systems
title_full_unstemmed Editing the Central Nervous System Through CRISPR/Cas9 Systems
title_short Editing the Central Nervous System Through CRISPR/Cas9 Systems
title_sort editing the central nervous system through crispr/cas9 systems
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546027/
https://www.ncbi.nlm.nih.gov/pubmed/31191241
http://dx.doi.org/10.3389/fnmol.2019.00110
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