Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding

Rhabdomyosarcoma (RMS) is an aggressive pediatric cancer composed of myoblast-like cells. Recently, we discovered a unique muscle progenitor marked by the expression of the Twist2 transcription factor. Genomic analyses of 258 RMS patient tumors uncovered prevalent copy number amplification events an...

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Detalles Bibliográficos
Autores principales: Li, Stephen, Chen, Kenian, Zhang, Yichi, Barnes, Spencer D., Jaichander, Priscilla, Zheng, Yanbin, Hassan, Mohammed, Malladi, Venkat S., Skapek, Stephen X., Xu, Lin, Bassel-Duby, Rhonda, Olson, Eric N., Liu, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546057/
https://www.ncbi.nlm.nih.gov/pubmed/30975722
http://dx.doi.org/10.1101/gad.324467.119

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