Bisubstrate analogues as structural tools to investigate m(6)A methyltransferase active sites

RNA methyltransferases (MTases) catalyse the transfer of a methyl group to their RNA substrates using most-often S-adenosyl-L-methionine (SAM) as cofactor. Only few RNA-bound MTases structures are currently available due to the difficulties in crystallising RNA:protein complexes. The lack of complex...

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Detalles Bibliográficos
Autores principales: Oerum, Stephanie, Catala, Marjorie, Atdjian, Colette, Brachet, Franck, Ponchon, Luc, Barraud, Pierre, Iannazzo, Laura, Droogmans, Louis, Braud, Emmanuelle, Ethève-Quelquejeu, Mélanie, Tisné, Carine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546350/
https://www.ncbi.nlm.nih.gov/pubmed/30879411
http://dx.doi.org/10.1080/15476286.2019.1589360

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