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Structural basis for the clamping and Ca(2+) activation of SNARE-mediated fusion by synaptotagmin

Synapotagmin-1 (Syt1) interacts with both SNARE proteins and lipid membranes to synchronize neurotransmitter release to calcium (Ca(2+)) influx. Here we report the cryo-electron microscopy structure of the Syt1–SNARE complex on anionic-lipid containing membranes. Under resting conditions, the Syt1 C...

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Detalles Bibliográficos
Autores principales:	Grushin, Kirill, Wang, Jing, Coleman, Jeff, Rothman, James E., Sindelar, Charles V., Krishnakumar, Shyam S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546687/ https://www.ncbi.nlm.nih.gov/pubmed/31160571 http://dx.doi.org/10.1038/s41467-019-10391-x

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