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Closed and open state dependent block of potassium channels cause opposing effects on excitability – a computational approach
Block of voltage-gated potassium (Kv) channels has been demonstrated to affect neuronal activity described as increasing excitability. The effect has been associated with a closed-state dependent block. However, the block of Kv channels in e.g. local anesthetic and antiarrhythmics, is open state-dep...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546692/ https://www.ncbi.nlm.nih.gov/pubmed/31160624 http://dx.doi.org/10.1038/s41598-019-44564-x |