Peroxiredoxin II negatively regulates BMP2-induced osteoblast differentiation and bone formation via PP2A Cα-mediated Smad1/5/9 dephosphorylation

Peroxiredoxin II (Prx II), an antioxidant enzyme in the Prx family, reduces oxidative stress by decreasing the intracellular ROS levels. Osteoblast differentiation is promoted by bone morphogenetic protein 2 (BMP2), which upregulates the expression of osteoblast differentiation marker genes, through...

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Detalles Bibliográficos
Autores principales: Kim, Kyeong-Min, Kim, Do-Young, Lee, Dong-Seok, Kim, Jung-Woo, Koh, Jeong-Tae, Kim, Eun-Jung, Jang, Won-Gu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546700/
https://www.ncbi.nlm.nih.gov/pubmed/31160554
http://dx.doi.org/10.1038/s12276-019-0263-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546700/
https://www.ncbi.nlm.nih.gov/pubmed/31160554
http://dx.doi.org/10.1038/s12276-019-0263-x

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