Cargando…

Comprehensive Characterization of a Next-Generation Antiviral T-Cell Product and Feasibility for Application in Immunosuppressed Transplant Patients

Viral infections have a major impact on morbidity and mortality of immunosuppressed solid organ transplant (SOT) patients because of missing or failure of adequate pharmacologic antiviral treatment. Adoptive antiviral T-cell therapy (AVTT), regenerating disturbed endogenous T-cell immunity, emerged...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amini, Leila, Vollmer, Tino, Wendering, Desiree J., Jurisch, Anke, Landwehr-Kenzel, Sybille, Otto, Natalie Maureen, Jürchott, Karsten, Volk, Hans-Dieter, Reinke, Petra, Schmueck-Henneresse, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546853/ https://www.ncbi.nlm.nih.gov/pubmed/31191530 http://dx.doi.org/10.3389/fimmu.2019.01148

Ejemplares similares

CRISPR-Cas9-Edited Tacrolimus-Resistant Antiviral T Cells for Advanced Adoptive Immunotherapy in Transplant Recipients
por: Amini, Leila, et al.
Publicado: (2021)

The Value of a Rapid Test of Human Regulatory T Cell Function Needs to be Revised
por: Wendering, Desiree J., et al.
Publicado: (2019)

Cyclosporine A but Not Corticosteroids Support Efficacy of Ex Vivo Expanded, Adoptively Transferred Human Tregs in GvHD
por: Landwehr-Kenzel, Sybille, et al.
Publicado: (2021)

Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial
por: Roemhild, Andy, et al.
Publicado: (2020)

Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients
por: Peter, Lena, et al.
Publicado: (2022)

Super-Treg: Toward a New Era of Adoptive Treg Therapy Enabled by Genetic Modifications
por: Amini, Leila, et al.
Publicado: (2021)

Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease
por: Landwehr-Kenzel, Sybille, et al.
Publicado: (2014)

HCoV- and SARS-CoV-2 Cross-Reactive T Cells in CVID Patients
por: Steiner, Sophie, et al.
Publicado: (2020)

Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function
por: Ou, Kristy, et al.
Publicado: (2021)

Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cells
por: Glaser, Viktor, et al.
Publicado: (2023)

Functional Surfactants for Molecular Fishing, Capsule Creation, and Single-Cell Gene Expression
por: Chowdhury, Mohammad Suman, et al.
Publicado: (2021)

Cas9-directed immune tolerance in humans—a model to evaluate regulatory T cells in gene therapy?
por: Wagner, Dimitrios Laurin, et al.
Publicado: (2021)

CAR NK-92 cell–mediated depletion of residual TCR(+) cells for ultrapure allogeneic TCR-deleted CAR T-cell products
por: Kath, Jonas, et al.
Publicado: (2023)

The role of soluble mediators in the clinical course of EBV infection and B cell homeostasis after kidney transplantation
por: Bajda, Sharon, et al.
Publicado: (2020)

Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells
por: Kath, Jonas, et al.
Publicado: (2022)

High-Mobility Group Box-1 Protein Serum Levels Do Not Reflect Monocytic Function in Patients with Sepsis-Induced Immunosuppression
por: Unterwalder, Nadine, et al.
Publicado: (2010)

Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners
por: Lei, Hong, et al.
Publicado: (2015)

To be, or not to be immunocompetent
por: Volk, Hans-Dieter, et al.
Publicado: (2013)

Antiviral/immunosuppressant: Various toxicities: case report
Publicado: (2020)

Antivirals/immunosuppressants: Various toxicities: 3 case reports
Publicado: (2021)

The TreaT-Assay: A Novel Urine-Derived Donor Kidney Cell-Based Assay for Prediction of Kidney Transplantation Outcome
por: Thieme, Constantin J., et al.
Publicado: (2019)

Batch Effects during Human Bone Marrow Stromal Cell Propagation Prevail Donor Variation and Culture Duration: Impact on Genotype, Phenotype and Function
por: Brachtl, Gabriele, et al.
Publicado: (2022)

Immunosuppressants and antiviral: COVID-19 and lack of efficacy: case report
Publicado: (2022)

Mechanisms of Immune Tolerance in Liver Transplantation-Crosstalk Between Alloreactive T Cells and Liver Cells With Therapeutic Prospects
por: Lei, Hong, et al.
Publicado: (2019)

Naive T cells inhibit the outgrowth of intractable antigen-activated memory T cells: implications for T-cell immunotherapy
por: Sharma, Sandhya, et al.
Publicado: (2023)

The next wave: immunizing the immunosuppressed
por: Michaelis, Laura C.
Publicado: (2021)

Genome-Scale Modeling Specifies the Metabolic Capabilities of Rhizophagus irregularis
por: Wendering, Philipp, et al.
Publicado: (2022)

COMMIT: Consideration of metabolite leakage and community composition improves microbial community reconstructions
por: Wendering, Philipp, et al.
Publicado: (2022)

Toward mechanistic modeling and rational engineering of plant respiration
por: Wendering, Philipp, et al.
Publicado: (2023)

Interaction of immunosuppressants with HCV antivirals daclatasvir and asunaprevir: combined effects with mycophenolic acid
por: de Ruiter, Petra E, et al.
Publicado: (2018)

Antivirals/immunosuppressants: COVID-19 infection and off label use: case report
Publicado: (2020)

Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations
por: Krech, Till, et al.
Publicado: (2010)

MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy
por: Moll, Guido, et al.
Publicado: (2020)

The Influence of Recovery and Training Phases on Body Composition, Peripheral Vascular Function and Immune System of Professional Soccer Players
por: Reinke, Simon, et al.
Publicado: (2009)

Immunosuppression and immunological tolerance induction: lessons from a transplant model
por: Filatenkov, A, et al.
Publicado: (2003)

Advanced Therapy Medicinal Products' Translation in Europe: A Developers' Perspective
por: Pizevska, Maja, et al.
Publicado: (2022)

Clinical adoptive regulatory T Cell therapy: State of the art, challenges, and prospective
por: Amini, Leila, et al.
Publicado: (2023)

Establishing Cell Models to Understand Cellular Toxicity: Lessons Learned from an Unconventional Cell Type
por: Vollmer, Tino, et al.
Publicado: (2022)

Enhanced Immunomodulation in Inflammatory Environments Favors Human Cardiac Mesenchymal Stromal-Like Cells for Allogeneic Cell Therapies
por: Diedrichs, Falk, et al.
Publicado: (2019)

Sequential Treatment by Antiviral Drugs Followed by Immunosuppressive Agents for COVID-19 Patients with Hematological Malignancy
por: Seki, Masafumi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1r23b4b57007dsn7v6ihj8ken4