Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling

RIF1 is a multifunctional protein implicated in controlling DNA replication and repair. Here, we show that human RIF1 protects nascent DNA from over-degradation at stalled replication forks. The major nuclease resecting nascent DNA in the absence of RIF1 is DNA2, operating with WRN as an accessory h...

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Detalles Bibliográficos
Autores principales: Garzón, Javier, Ursich, Sebastian, Lopes, Massimo, Hiraga, Shin-ichiro, Donaldson, Anne D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547018/
https://www.ncbi.nlm.nih.gov/pubmed/31141682
http://dx.doi.org/10.1016/j.celrep.2019.05.002

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