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Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge

Epidemiological studies suggest skeletal growth is programmed during intrauterine and early postnatal life. We hypothesize that bone development may be altered by maternal diet and have investigated this using a microswine model of maternal protein restriction (MPR). Mothers were fed a control diet...

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Autores principales: Lanham, Stuart A., DuPriest, Elizabeth, Kupfer, Philipp, Cooper, Cyrus, Bagby, Susan P., Oreffo, Richard O. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547064/
https://www.ncbi.nlm.nih.gov/pubmed/31161709
http://dx.doi.org/10.14814/phy2.14081
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author Lanham, Stuart A.
DuPriest, Elizabeth
Kupfer, Philipp
Cooper, Cyrus
Bagby, Susan P.
Oreffo, Richard O. C.
author_facet Lanham, Stuart A.
DuPriest, Elizabeth
Kupfer, Philipp
Cooper, Cyrus
Bagby, Susan P.
Oreffo, Richard O. C.
author_sort Lanham, Stuart A.
collection PubMed
description Epidemiological studies suggest skeletal growth is programmed during intrauterine and early postnatal life. We hypothesize that bone development may be altered by maternal diet and have investigated this using a microswine model of maternal protein restriction (MPR). Mothers were fed a control diet (14% protein) or isocaloric low (1%) protein diet during late pregnancy and for 2 weeks postnatally. Offspring were weaned at 4 weeks of age to ad lib or calorie‐restricted food intake groups. Femur and vertebra were analysed by micro computed tomography in offspring 3–5 months of age. Caloric restriction from 4 weeks of age, designed to prevent catch‐up growth, showed no significant effects on bone structure in the offspring from either maternal dietary group. A maternal low protein diet altered trabecular number in the proximal femur and vertebra in juvenile offspring. Cortical bone was unaffected. These results further support the need to understand the key role of the nutritional environment in early development on programming of skeletal development and consequences in later life.
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spelling pubmed-65470642019-06-06 Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge Lanham, Stuart A. DuPriest, Elizabeth Kupfer, Philipp Cooper, Cyrus Bagby, Susan P. Oreffo, Richard O. C. Physiol Rep Original Research Epidemiological studies suggest skeletal growth is programmed during intrauterine and early postnatal life. We hypothesize that bone development may be altered by maternal diet and have investigated this using a microswine model of maternal protein restriction (MPR). Mothers were fed a control diet (14% protein) or isocaloric low (1%) protein diet during late pregnancy and for 2 weeks postnatally. Offspring were weaned at 4 weeks of age to ad lib or calorie‐restricted food intake groups. Femur and vertebra were analysed by micro computed tomography in offspring 3–5 months of age. Caloric restriction from 4 weeks of age, designed to prevent catch‐up growth, showed no significant effects on bone structure in the offspring from either maternal dietary group. A maternal low protein diet altered trabecular number in the proximal femur and vertebra in juvenile offspring. Cortical bone was unaffected. These results further support the need to understand the key role of the nutritional environment in early development on programming of skeletal development and consequences in later life. John Wiley and Sons Inc. 2019-06-04 /pmc/articles/PMC6547064/ /pubmed/31161709 http://dx.doi.org/10.14814/phy2.14081 Text en © 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Lanham, Stuart A.
DuPriest, Elizabeth
Kupfer, Philipp
Cooper, Cyrus
Bagby, Susan P.
Oreffo, Richard O. C.
Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge
title Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge
title_full Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge
title_fullStr Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge
title_full_unstemmed Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge
title_short Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge
title_sort altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547064/
https://www.ncbi.nlm.nih.gov/pubmed/31161709
http://dx.doi.org/10.14814/phy2.14081
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