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Porphyria Cutanea Tarda Associated With Acute Hemorrhagic Pancreatitis
Porphyria cutanea tarda (PCT) is a condition of dysregulated heme synthesis that leads to accumulation of photosensitizing precursors with resultant fragility and blistering of the skin. It can be hereditary or acquired and has been known to be associated with hepatic C virus, alcohol, HIV, and estr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547174/ https://www.ncbi.nlm.nih.gov/pubmed/31155958 http://dx.doi.org/10.1177/2324709619852769 |
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author | Singh, Manasi Duckett, Ashley Heincelman, Marc |
author_facet | Singh, Manasi Duckett, Ashley Heincelman, Marc |
author_sort | Singh, Manasi |
collection | PubMed |
description | Porphyria cutanea tarda (PCT) is a condition of dysregulated heme synthesis that leads to accumulation of photosensitizing precursors with resultant fragility and blistering of the skin. It can be hereditary or acquired and has been known to be associated with hepatic C virus, alcohol, HIV, and estrogen. In this article, we report an unusual presentation of PCT associated with acute hemorrhagic pancreatitis in a 57-year-old man. He presented initially to a community hospital with acute onset of epigastric abdominal pain and new-onset ascites. Lipase was elevated. Diagnostic paracentesis was grossly bloody. He was then transferred to our institution for concern for acute hemorrhagic pancreatitis. On arrival, physical examination demonstrated vesicles and bullae with erythematous bases, in different stages of healing seen over the dorsal aspects of both hands with scaling, scarring, and hypopigmentation and hyperpigmentation of the skin. Laboratory evaluation and skin biopsy confirmed the diagnosis of PCT. Search for an underlying etiology failed to reveal typical predisposing factors. This report illustrates that acute hemorrhagic pancreatitis may be an underlying etiology for PCT. |
format | Online Article Text |
id | pubmed-6547174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-65471742019-06-17 Porphyria Cutanea Tarda Associated With Acute Hemorrhagic Pancreatitis Singh, Manasi Duckett, Ashley Heincelman, Marc J Investig Med High Impact Case Rep Case Report Porphyria cutanea tarda (PCT) is a condition of dysregulated heme synthesis that leads to accumulation of photosensitizing precursors with resultant fragility and blistering of the skin. It can be hereditary or acquired and has been known to be associated with hepatic C virus, alcohol, HIV, and estrogen. In this article, we report an unusual presentation of PCT associated with acute hemorrhagic pancreatitis in a 57-year-old man. He presented initially to a community hospital with acute onset of epigastric abdominal pain and new-onset ascites. Lipase was elevated. Diagnostic paracentesis was grossly bloody. He was then transferred to our institution for concern for acute hemorrhagic pancreatitis. On arrival, physical examination demonstrated vesicles and bullae with erythematous bases, in different stages of healing seen over the dorsal aspects of both hands with scaling, scarring, and hypopigmentation and hyperpigmentation of the skin. Laboratory evaluation and skin biopsy confirmed the diagnosis of PCT. Search for an underlying etiology failed to reveal typical predisposing factors. This report illustrates that acute hemorrhagic pancreatitis may be an underlying etiology for PCT. SAGE Publications 2019-06-03 /pmc/articles/PMC6547174/ /pubmed/31155958 http://dx.doi.org/10.1177/2324709619852769 Text en © 2019 American Federation for Medical Research http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Singh, Manasi Duckett, Ashley Heincelman, Marc Porphyria Cutanea Tarda Associated With Acute Hemorrhagic Pancreatitis |
title | Porphyria Cutanea Tarda Associated With Acute Hemorrhagic
Pancreatitis |
title_full | Porphyria Cutanea Tarda Associated With Acute Hemorrhagic
Pancreatitis |
title_fullStr | Porphyria Cutanea Tarda Associated With Acute Hemorrhagic
Pancreatitis |
title_full_unstemmed | Porphyria Cutanea Tarda Associated With Acute Hemorrhagic
Pancreatitis |
title_short | Porphyria Cutanea Tarda Associated With Acute Hemorrhagic
Pancreatitis |
title_sort | porphyria cutanea tarda associated with acute hemorrhagic
pancreatitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547174/ https://www.ncbi.nlm.nih.gov/pubmed/31155958 http://dx.doi.org/10.1177/2324709619852769 |
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